Glutamine Combined With Thalidomide in Preventing Radiation-induced Oral Mucositis

Inclusion Criteria: 1. Age 18 to 75 years old; 2. Patients with locoregional advanced squamous cell carcinoma confirmed by pathological histology or cytology and requiring radiotherapy or concurrent chemoradiotherapy; 3. Patients who have received more than 45Gy of radiation in the oral area; 4. ECOG PS (Eastern Cooperative Oncology Group Performance Status) score of 0-1; 5. Basic hematological indicators are normal: White blood cell count ≥ 4×10\^9/L; Absolute neutrophil count ≥ 1.5×10\^9/L; Platelets ≥ 100×10\^9/L; Hemoglobin ≥ 90 g/L; 6. Basic renal function is normal: Serum creatinine ≤ 1.5×ULN (Upper Limit of Normal) or Creatinine Clearance Rate (CrCl) \> 60 mL/min (using the Cockcroft-Gault formula): For women: CrCl = (140 - age) × weight (kg) × 0.85 / (72 × Scr mg/dl) For men: CrCl = (140 - age) × weight (kg) × 1.00 / (72 × Scr mg/dl) 7. Basic liver function is normal: Serum total bilirubin ≤ 1.5×ULN; AST (Aspartate Aminotransferase) ≤ 2.5×ULN; ALT (Alanine Aminotransferase) ≤ 2.5×ULN. 8. Signed written informed consent. Exclusion Criteria: 1. Participated in another interventional clinical trial within the last 30 days; 2. Patients with severe underlying oral diseases who cannot tolerate radiation therapy; 3. Patients allergic to glutamine and thalidomide; 4. Patients receiving secondary radiation therapy to the oral area; 5. Pregnant women (confirmed by blood or urine HCG testing) or breastfeeding women, or participants of childbearing age who are unwilling or unable to take effective contraceptive measures (applicable to both male and female participants) until at least 6 months after the last trial treatment; 6. Patients with underlying peripheral neuropathy; 7. Individuals deemed by the researcher to be inappropriate for participation in this study; 8. Unwilling to participate in this study or unable to sign informed consent.