The goal of this observational study is to learn about the prevalence and characteristics of functional gastrointestinal disorders (FGID) in at risk infants (former preterm infants and those with birth asphyxia) during the first 2 years of life. The main questions it aims to answer are: * evaluate the prevalence of symptoms related to gastro-esophageal reflux (GER), of functional gastrointestinal disorders during the first 2 years of life * describe growth parameters during follow-up up to the corrected age of 2 years Participants will be assessed clinically and with a structured questionnaire based on the Rome IV criteria to describe FGID.
Infants will undergo clinical assessment at 3, 6, 12, 24 months' corrected age at the local Follow-up clinic. Clinical examination, anthropometric measurement and data from a structured questionnaire to detect FGID will be performed. Z-scores for weight, length and head circumference will be calculated according to the World Health Organization (WHO) standards. Data from the questionnaires will be collected. Clinical characteristics of patients and perinatal data will be collected and analyzed by appropriate statistical methods. The prevalence and characteristics of FGID in the study population will be compared to published data (mostly from term infants).
Study Type
OBSERVATIONAL
Enrollment
71
At each follow up visit, a clinical examination and anthropometric evaluation will be performed. Parents will fill a structured questionnaire to describe the occurrence and characteristics of functional gastrointestinal disorders.
Fondazione Policlinico Gemelli IRCCS
Roma, Italy
RECRUITINGPrevalence of FGID
Occurrence of FGID (percentage of patients)
Time frame: 3, 6, 12, 24 months of corrected age
Frequency of FGID
Frequency of FGID (i.e. number of symptoms per day)
Time frame: 3, 6, 12, 24 months of corrected age
Severity of FGID
Severity (scales from 0 to 10 for increasing values) of FGID
Time frame: 3, 6, 12, 24 months of corrected age
Somatic growth: weight
Measurement of weight and calculation of z-scores based on reference standards by the World Health Organization
Time frame: 3, 6, 12, 24 months of corrected age
Somatic growth: head circumference
Measurement of head circumference and calculation of z-scores based on reference standards by the World Health Organization
Time frame: 3, 6, 12, 24 months of corrected age
Somatic growth: length
Measurement of length and calculation of z-scores based on reference standards by the World Health Organization
Time frame: 3, 6, 12, 24 months of corrected age
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.