The Optimal Dose of Indomethacin Suppository for Preventing Post-ERCP Pancreatitis

Inclusion Criteria: * According to the "Chinese ERCP Guidelines (2018 Edition)", patients with various biliary and pancreatic diseases who have indications for ERCP examination and treatment, who are at least 18 years old and have no contraindications, and who can tolerate the examination; * Preoperative blood coagulation function, liver and kidney function indicators are in the normal range; * The patients agreed to participate in this experiment, signed the informed consent form, and was approved by the hospital ethics committee. Exclusion Criteria: * Contraindications to indomethacin and other NSAIDs: such as allergy to indomethacin, severe heart failure, active peptic ulcer/bleeding, perioperative period of coronary artery bypass surgery, etc.; * There are severe cardiovascular and cerebrovascular diseases, respiratory insufficiency and coagulation dysfunction, etc., and cannot tolerate ERCP examination; * Those who have recently used indomethacin and other non-steroidal anti-infective drugs; * Pregnant or lactating women.