The drug-drug interaction study had been designed to investigate the effect of Leritrelvir on the pharmacokinetics of Midazolam, Omeprazole, Rosuvastatin and the effect of Verapamil and Rifampin on the pharmacokinetics of Leritrelvir
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
56
the Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Pharmacokinetic - Cmax
Maximum observed plasma concentration
Time frame: 0-72 hours
Pharmacokinetic -Area under the curve(AUC)
Area under the curve
Time frame: 0-72 hours
Number of participants with adverse events
The safety and tolerability of Leritrelvir alone and in combination with Midazolam, Omeprazole, Rosuvastatin, Verapamil, and Rifampin will be examined.
Time frame: Day1-Day31
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