Application of Serum Bile Acid Profile in the Diagnosis of Gastric Cancer

Inclusion Criteria: 1. Age between 18-70, both gender; 2. The gastric cancer group was early gastric cancer or advanced gastric cancer diagnosed by endoscopic examination and pathological biopsy. The non-gastric cancer group included patients without gastric lesions, superficial gastritis, chronic atrophic gastritis, intestinal metaplasia or dysplasia diagnosed by gastroscopy or pathological biopsy; 3. Informed consent was obtained. Exclusion Criteria: 1. The patients have diseases that affect bile acid metabolism, such as liver cirrhosis, gallstones or inflammatory bowel disease, Behcet's disease, etc; 2. Due to other diseases, the patient took drugs affecting bile acid metabolism, such as cholestyramine, anti-inflammatory Lidan tablets, Danshu capsules, ursodeoxycholic acid, obticholic acid, Schisandrin B, tanshinone ⅡA, Yinzhihuang, etc; 3. Pregnant women; 4. Primary tumors of other systems were diagnosed; 5. Those with poor physiopathological conditions, such as chronic kidney disease requiring long-term dialysis; 6. Patients with mental illness; 7. Patients who have received radiotherapy or surgery previously; 8. Those with poor adherence or difficult to follow up.