The aim of the present pilot randomized controlled trial is to compare the effects of the following: 1)-panettone enriched with arabinoxylans (p-rich), 2)-panettone not enriched (p-standard) on blood glucose and insulin values, and appetite scores in 10 healthy volunteers.
This is a crossover, randomized double-blind trial. A product enriched with arabinoxylan extracted from threshing (panettone, p-rich, a sweet baked product with a high glycemic index) was developed to assess the impact on metabolic responses and satiety when compared to the standard product (p-standard) . Ten Caucasian non-smoker healthy adult volunteers were enrolled starting from January 2023. Participants were randomized to receive either the p-rich or p-standard. The order of administration of each product was randomized using a computer-generated sequence. The day of each test, fasting individuals underwent a blood sample collection, and weight and height measurements. Then, participants consumed 100 grams of the product within 20 minutes, while sitting. Blood samples were collected at 15, 30, 45, 60, 90, 120 minutes after the consumption of each food.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
10
Volunteers consumed 100 grams of panettone enriched with fiber (JAX Plus® (Heallo srl, Milano, Italy), a soluble fiber with Arabinoxylans from wheat and barley
Volunteers consumed 100 grams of panettone standard
University of Turin
Turin, AT, Italy
Changes in circulating concentrations of glucose
To evaluate changes in glucose responses after the consumption of p-rich when compared to p-standard
Time frame: 15, 30, 45, 60, 90, 120 minutes after the consumption of each food
Changes in circulating concentrations of insulin
To evaluate changes in insulin responses after the consumption of p-rich when compared to p-standard
Time frame: 15, 30, 45, 60, 90, 120 minutes after the consumption of each food
Changes in subjective appetite score (VAS)
To evaluate changes in appetite responses after the consumption of p-rich when compared to p-standard. Subjective sensations of appetite were assessed by a visual analogue scale (VAS) ranging from 0 to 10.
Time frame: 60, 120, 180, and 240 minutes after the consumption of each food
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