The effect of mailing FIT with the invitation on participation and colonoscopy rates will be evaluated in a randomized controlled trial conducted in the Centre-Val de Loire (CVL) region, involving 64,000 people from the population eligible for colorectal cancer population-based organised screening program (CRC-PBOSP). In the "C" control group, invitations, test delivery and reminders will be carried out in accordance with the CRC-PBOSP rules at the time of the study. Intervention group "B" will evaluate two experimental modes of invitation with direct home mailing of the test: * Method "B1": invitation with test sent to home without prior information letter * Method "B2": information letter followed by invitation with test sent home, designed to optimize participation by first-time subjects (aged 50-51) invited to the CRC-PBOSP for the first time. Ancillary studies will focus 1/ on acceptability of this intervention (qualitative study on a few general practitioners, gastroenterologists and invitees), 2/ on social and geographical inequalities of participation on a subsample of individuals included in EXPEDIT study using ecological indices (EDI, SCALE).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
64,000
The invitation to CRC-PBOSP will only contain informations on how to get the screening test.
The invitation to CRC-PBOSP will contain the CRC screening test.
An information letter will be sent to future invitees a few weeks before the invitation, to announce the mailing of the CRC screening kit.
Crcdc-Cvl
Tours, France
RECRUITINGParticipation to CRC screening program
Rate of FIT sent to laboratory for analysis within 16 of months of invitation among invitees.
Time frame: 16 months after the invitation
Performance of colonoscopy in FIT positive patients
Rate of Colonoscopy within 6 months after positive FIT among invitees with a positive FIT
Time frame: 6 months after the positive FIT
Participation to CRC screening program at 24 months
Rate of FIT sent to laboratory for analysis within 24 of months of invitation among invitees.
Time frame: 24 months after invitation
Time to screening participation
Time to screening participation within 24 months of invitation among invitees
Time frame: 24 months after invitation
Colonoscopy in FIT positive patients, 12 months after the positive test
Rate of Colonoscopy within 12 months after positive FIT among invitees with a positive FIT
Time frame: 12 months after the positive test
Time to colonoscopy (in FIT positive patients)
Time from FIT to colonoscopy within 12 months of positive FIT among invitees with a positive FIT
Time frame: 12 months after the positive test
Colonoscopy findings
Rate of colorectal cancer or advanced neaplasia in invitees with a positive FIT
Time frame: 12 months after the positive test
Participation to CRC screening program in first invitees (50-51 yrs-old)
Rate of FIT sent to laboratory for analysis within 16 of months of invitation among first invitees (50-51 yrs-old)
Time frame: 16 months after invitation
Cost-effectiveness analysis
Costs of CSC-PBOSP from invitation to colonoscopy when necessary
Time frame: 24 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.