Eccentric Resistance Training Among Individuals With Chronic Heart Failure

Riphah International University84 enrolled

Overview

To determine the effects of eccentric resistive training on ventricle functions and aerobic capacity as compared to a resistance and aerobic training among Heart failure (HF)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Heart Failure

Interventions

Eccentric Resistive Training + Aerobic training GroupOTHER

Eccentric Resistive training includes upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings) 2 sets of 12 repetitions (reps) for each group of muscles in lengthened position for eccentric training in approx. 20 minutes (min). Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair descending training and squatting position and eccentric hamstring curls with weights at ankle for lower limb eccentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain) . (approx. 20 min). \+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.

Resistance Training + Aerobic training GroupOTHER

Resistive training (concentric) includes Upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings), 2 sets of 12 reps for each group of muscles in approx. 30 min. Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair climbing training and quadriceps training + standing hamstring curls with weight at ankle for lower limb concentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain) \+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of Chronic HF and currently stable with optimal medical therapy * Chronic Heart failure with ejection fraction \> 30 % * Patient able to safely perform lower limb exercise will be check by six- minute walk test (6 MWT) Exclusion Criteria: * Those Heart failure patient whose are in acute phase or planed for any immediate medical intervention * Already participating in cardiac rehabilitation * New York Heart Association (NYHA) Classification of HF class IV HF symptoms * Co-existent other disease such as asthma/ COPD/interstitial lung disease. * Symptomatic Second degree or third degree heart block. * ECG with uncontrolled ventricular arrhythmia * Limited Exercise ability due to neurologic or orthopedic impairments of the legs (will cross-check with 6 MWT)

Locations (2)

Pakistan Railway Hospital

Rawalpindi, Punjab Province, Pakistan

SUSPENDED

Rawalpindi Institute of Cardiology

Rawalpindi, Punjab Province, Pakistan

RECRUITING

Outcomes

Primary Outcomes

Ventricle Functions

Changes from the baseline will be measured. Doppler resting echocardiography will be performed to measure ventricle functions. Standard views, including the parasternal long-axis, short-axis at the papillary muscle level, and apical 4- and 2-chamber views will be recorded. Left ventricular ejection fraction (LVEF) and end systolic and end-diastolic diameters (LVESD and LVEDD) will be measured using formula (Tiecholz formula i-e spherical volume of the heart multiplied by a correction factor). Any structural changes will also be recorded.

Time frame: 12 week

Aerobic Capacity

Changes will be measured at baseline, 4th week, 8th week and 12th week. The 6-min walk test provides an indirect measure of cardiovascular functional/aerobic capacity. Six Minute Walk test (6MWT) will be used to assess the functional capacity of the individuals with HF. The subjects will be instructed to walk for 6 minutes at a given time along a 30-m line at an interval of 1.5 m in an outdoor corridor, and the distance walked will be recorded in meters. The participants will be encouraged to continue walking as fast as possible. Then a generalized equation will be used to predict peak VO2 from 6 minute walk distance (6MWD) with the help of formula. Mean Peak VO2 (ml/kg/Mean) = 4.948 + 0.023 \*Mean 6MWD (meters)

Time frame: 12 week

Secondary Outcomes

Quality of life (Minnesota Living with Heart Failure Questionnaire)

Changes from the baseline will be measured. Quality of life will be measured through Minnesota Living with Heart Failure Questionnaire (MLHFQ). It is one of the most widely used health-related quality of life questionnaires for individuals with HF. It provides scores for two dimensions, physical and emotional, and a total score. The MLHFQ is a self-administered, 21-item disease-specific instrument for individuals with HF. Each item is scored in a 6-point Likert Scale (0 to 5), thus the total score could range from 0 to 105, with higher scores indicating more significant impairment in health-related quality of life. The MLHFQ has two domains; physical domain (eight items, score range from 0 to 40) and emotional domain (five items, score range from 0 to 25).

Central Contacts

Muhammad Iqbal Tariq, PhD*

CONTACT

+923338236752 iqbal.tariq@riphah.edu.pk

Data from ClinicalTrials.gov

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