Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid

Alexandria University30 enrolled

Overview

Numerous materials are nowadays used in the fabrication of healing abutments to be used for dental implants. soft tissue response to different healing abutment materials is still to be unraveled. the Aim of this study is to compare the soft tissue response to titanium stock healing abutments to customized composite healing abutments through assessing the level of matrix metalloproteinase-8 in the peri-implant crevicular fluid

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Dental Implants

Interventions

Stock healing abutmentsOTHER

2ND stage surgery will be performed and stock healing abutment were placed

Compoiste healing abutmentsOTHER

2ND stage surgery will be performed and composite healing abutment were placed

Eligibility

Sex: ALLMin age: 25 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with no systemic and/or oral health disease * absence of any lesions in the oral cavity * wide band of keratinized tissue more than 1mm at implant site Exclusion Criteria: * smoking more than 20 cigarettes per day * localized radiation therapy of the oral cavity, * antitumor chemotherapy, liver diseases, blood diseases, kidney diseases, immunosuppressed patients, patients taking corticosteroids, pregnancy, inflammatory and autoimmune diseases of the oral cavity

Locations (1)

Alexandria Faculty of Dentistry

Alexandria, Egypt

Outcomes

Primary Outcomes

Change in MMP8 levels

Measuring MMP-8 level around composite and titanium healing abutments with ELISA kit

Time frame: at 2 weeks and 4 weeks

Secondary Outcomes

Change in gingival condition

Modified gingival index was used to assess gingival condition The MGI uses a rating score between 0 and 4 0 = absence of inflammation 1. = mild inflammation 2. = mild inflammation 3. = moderate inflmmation 4. = severe inflammation

Time frame: at 2 weeks and 4 weeks

Change in gingival bleeding

Bleeding index will be recorded as present or absent

Time frame: at 2 weeks and 4 weeks

Change in plaque accumulation

Plaque index 0: No plaque is in the area adjacent to the gingiva. Plaque index 1: There is a plaque in the form of a thin film on the gingival margin. Plaque index 2: There is a visible plaque in the gingival pocket and gingival margin. Plaque index 3: There is a dense plaque in the gingival pocket and on the gingival margin.

Time frame: at 2 weeks and 4 weeks

Data from ClinicalTrials.gov

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