This study aimed to determine the therapeutic effectiveness of different machines in intense pulsed light (IPL) treatment of meibomian gland dysfunction (MGD). Subjects diagnosed with MGD underwent three sessions of IPL treatment in a control (M22) treatment group or experimental (OPL-I) treatment group and were followed up three to four weeks after each session. Tear breakup time (TBUT), meibomian gland secretion scores (MGSS), meibomian gland meibum scores (MGMS), corneal fluorescein staining (CFS) scores, and the Standard Patient Evaluation of Eye Dryness (SPEED) was used to assess eye dryness signs and symptoms at baseline and follow-up visits.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
216
Each MGD patient underwent three treatment sessions at three-week intervals and three follow-up examinations over the course of treatment.
0.3% hyaluronic acid eye drops (Hialid; Santen, Osaka, Japan) four times a day during the study, including the follow-up period.
Hankou Aier Eye Hospital, Wuhan，Hubei Province
Wuhan, Hubei, China
Wuhan Aier Eye Hospital, Wuhan，Hubei Province
Wuhan, Hubei, China
2nd Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
SPEED Scores
Standard Patient Evaluation of Eye Dryness questionnaire
Time frame: Baseline, 1 month, 2 months, 3 months, 4 months
CFS scores
corneal fluorescein staining scores
Time frame: Baseline, 1 month, 2 months, 3 months, 4 months
TBUT
Tear breakup time
Time frame: Baseline, 1 month, 2 months, 3 months, 4 months
MGSS
Meibomian gland secretion scores. The MGSS evaluates the obstruction of meibum along the lower eyelid. Three positions along the lower eyelid were detected (five nasal, five central, and five temporal meibomian glands). A score of 0 indicated secretion by all five glands, a score of 1 indicated secretion by three to four glands, a score of 2 indicated secretion by one or two glands, and a score of 3 indicated no secretion by any glands.
Time frame: Baseline, 1 month, 2 months, 3 months, 4 months
MGMS
meibomian gland meibum scores. The MGMS evaluates the quality of meibum along the lower eyelid, with a score of 0 indicating clear liquid meibum, a score of 1 indicating cloudy liquid meibum, a score of 2 indicating cloudy granular meibum, and a score of 3 indicating toothpaste-like solid meibum).
Time frame: Baseline, 1 month, 2 months, 3 months, 4 months
BCVA
best-corrected visual acuity
Time frame: Baseline, 4 months
IOP
intraocular pressure measurements
Time frame: Baseline, 4 months
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