Food Effect Study of Brexpiprazole Once-weekly (QW) Formulation in Patients With Schizophrenia

Inclusion Criteria: * Patients with a diagnosis of schizophrenia based on DSM-5® at the time of informed consent * Patients who are able to be hospitalized for the protocol-defined hospitalization period * Patients with a body mass index \[BMI = body weight (kg)/height (m)²\] of 18.5 kg/m² or higher and lower than 35.0 kg/m² at screening * Patients who, in the judgment of the investigator, have stable psychotic symptoms maintained by administration of an antipsychotic within the dosing range indicated below, before commencement of IMP administration \[Upper limit of dose and regimen\] Antipsychotic medication comprising no more than 2 active components, and a daily dose equivalent to ≤600 mg/day of chlorpromazine * Patients who are able to finish the high-fat meal specified in this protocol within 20 minutes Exclusion Criteria: * Patients with a concurrent mental disorder besides schizophrenia who are judged by the investigator to be unsuitable for participation in the trial * Patients who have met the DSM-5® diagnostic criteria for substance-related or addictive disorder, including alcohol and benzodiazepines but excluding caffeine and tobacco, within 180 days before commencement of investigational medicinal product (IMP) administration * Patients who fall under any of the following criteria regarding suicidal ideation and suicidal behavior * Patients who answered "yes" to Question 4 "Active Suicidal Ideation with Some Intent to Act, without Specific Plan" or Question 5 "Active Suicidal Ideation with Specific Plan and Intent" regarding C-SSRS suicidal ideation at screening (for the past 6 months) or at the Period 1 baseline examination (since the last assessment) * Patients who exhibited suicidal behavior on C-SSRS at screening (for the past 2 years) or at the Period 1 baseline examination (since the last assessment) * Patients who present a serious risk of suicide based on the judgment of the investigator * Patients who have previously undergone gastrointestinal surgery that could affect PK evaluation * Patients who have a clinically significant neurological, hepatic, renal, metabolic, hematological, immunological, cardiovascular, pulmonary, or gastrointestinal disorder. Medical conditions that are minor or well-controlled may be considered acceptable if the condition does not interfere with safety and PK assessments. * Patients who are using clozapine at the time of informed consent * Patients whose clinical symptoms have worsened to the point where use of prohibited concomitant therapy or medication is required during the washout period for prior medication * Patients whose cytochrome P450 2D6 (CYP2D6) phenotype is judged to be either poor metabolizers (PM) or Unknown based on the results of CYP2D6 genotyping at screening