The main purpose of this study is to explore the PK/PD changes of NMN and DC cells after oral NMN combined with DC cells injection in patients after tumor surgery, and evaluate the biological age of adults, TCR diversity, SiRT1 expression level, SF-36 quality of life, OS, antigen specific immune response (TAA), cytokines and so on. In this study, 20 postoperative tumor patients who meet the entry and excretion criteria were recruited to explore the clinical potential of NMN combined with DC cell vaccine.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
The whole intervention cycle was treated with NMN (Vital NAD) 600mg/day for at least 50 days. During this period, the first DC cell injection was given on the 10th day, and then another DC cell injection was given at 2 weeks, 4 weeks and 6 weeks after the first injection.
Shanghai Mengchao Cancer Hospital
Shanghai, Shanghai Municipality, China
Concentration of double antibodies in peripheral blood
Time frame: Up to 3 months
Concentration of NMN (nicotinamide mononucleotide) in peripheral blood
Time frame: Up to 3 months
Peripheral blood NAD+
Time frame: Up to 3 months
Cytokines (IL6, TNF- goat, INF- γ, IL-4, IL-10)
Time frame: Up to 3 months
T cell depletion index (PD1/Tim-3/lag3)
Time frame: Up to 3 months
T cell activation index CD107
Time frame: Up to 3 months
T cell and NK cell function index (INF- γ) and granzyme
Time frame: Up to 3 months
High quality Survival benefit Endpoint (DFS)
DFS refers to the time from the beginning of treatment to the recurrence of the disease or the death of the patient. Patients need to be followed up regularly to keep records.
Time frame: Up to 15 years
Survival benefit (OS)
OS refers to the time from the beginning of randomization to death (for any reason). Patients need to be followed up regularly to keep records.
Time frame: Up to 15 years
Distant Metastasis-Free Survival (DMFS)
Metastasis-free survival time. Patients need to be followed up regularly to keep records.
Time frame: Up to 15 years
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