Uterine Peristalsis in IVF

N/ANot Yet RecruitingNCT06036459

Assiut University117 enrolled

Overview

An observational prospective cohort study to evaluate the effect of uterine peristalsis at the time of embryo transfer on IVF clinical outcomes performed in Women's Health hospital, Assiut University, Egypt. Women performing fresh or frozen embryo transfer who do not have any uterine abnormalities will be included in the study

Study Type

OBSERVATIONAL

Enrollment

117

Conditions

Infertility, Female

Interventions

uterine peristalsisOTHER

Transabdominal us followed by Transvaginal ultrasonography scans (Sono Ace R5 ) of uterine peristalsis will performed on the day of embryo transfer while the patient lying relaxed in lithotomy position. The probe will be introduced into the vagina as gently as possible to avoid stimulating the cervix. After scanning the mid-sagittal plane of the uterus, the probe will be fixed as steady as possible while a 3 min video of uterine peristalsis will be recorded simultaneously. The records will be analyzed at 4X regular speed using a Video player application by two independent experienced observers. The uterine peristaltic wave frequency will be the mean of the results from each observer.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * • Women undergoing embryo transfer during IVF cycles. * Age: between 20 and 40 years. * Have at least 1 good quality embryo at the time of transfer * Fresh or frozen-thawed cycles. * Any stimulation protocol in fresh cycles, or any endometrial preparation protocol for frozen-thawed cycles Exclusion Criteria: * • Women refusing to participate in clinical research. * Any uncorrected uterine abnormality, such as septum, myoma, adenomyosis, or polyp * Hydrosalpinx without prior disconnection or excision

Outcomes

Primary Outcomes

Clinical pregnancy

The presence of intrauterine gestational sac and fetal pole with positive cardiac pulsation by transvaginal ultrasound

Time frame: 2 weeks after a positive pregnancy test

Secondary Outcomes

Biochemical pregnancy

a positive serum human chorionic gonadotropin

Time frame: 2 weeks after embryo transfer

Miscarriage

Pregnancy loss either loss of cardiac pulsation by ultrasound, or spontaneous loss of pregnancy vaginally

Time frame: From 6 weeks of gestation until 28 weeks of gestation

Ectopic pregnancy

Pregnancy outside the uterine cavity

Time frame: the site of the gestational sac will be assessed 2 weeks after embryo transfer

Ongoing pregnancy

The presence of a viable pregnancy after 12 weeks of gestation

Time frame: After 12 weeks of gestation until delivery

Live birth

Delivery of a living foetus after the age of viability

Time frame: From 28 weeks of gestation until delivery

Central Contacts

Karim Abdallah, MD

CONTACT

+201270595485 karimsayed88@aun.edu.eg

Data from ClinicalTrials.gov

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