The investigators planned this study to investigate the effects of dexmedetomidine administration on intraoperative hemodynamic stability in patients with pheochromocytoma.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
40
In the dexmedetomidine group, dexmedetomidine is administered at a rate of 0.5 μg/kg/h immediately after anesthesia induction and continued until the completion of the surgery. The research nurse, who did not participate in the study other than the management and preparation of the study medication, prepared 50mL of 0.9% normal saline for the control group and a mixture of dexmedetomidine 2 mL and 0.9% normal saline 48 mL (at a concentration of 4 μg/mL) for the dexmedetomidine group.
In the control group, a 0.9% normal saline infusion is initiated at the same rate immediately after anesthesia induction and continued until the end of the operation.
Severance hospital
Seoul, South Korea
Intraoperative hemodynamic stability ( maximum blood pressure during surgery (systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP))
Time frame: during operation
Intraoperative hemodynamic stability (duration of SBP increase by 30% or more from baseline (in minutes)
Time frame: during operation
Intraoperative hemodynamic stability (duration of SBP exceeding 200 mmHg)
Time frame: during operation
Intraoperative hemodynamic stability (maximum HR during surgery)
Time frame: during operation
Intraoperative hemodynamic stability (duration of HR exceeding 110 beats per minute during surgery)
Time frame: during operation
Intraoperative hemodynamic stability (comparison of the quantity of vasoactive drugs (nitroprusside, esmolol, norepinephrine) used during surgery)
Time frame: during operation
levels of catecholamines
the actual secretion levels of catecholamines, specifically epinephrine and norepinephrine, were measured at different time points
Time frame: immediately after anesthesia induction
levels of catecholamines
the actual secretion levels of catecholamines, specifically epinephrine and norepinephrine, were measured at different time points
Time frame: immediately after removal of the pheochromocytoma
levels of catecholamines
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the actual secretion levels of catecholamines, specifically epinephrine and norepinephrine, were measured at different time points
Time frame: immediately after the completion of surgery