The incidence of thyroid cancer has increased rapidly in recent years, especially in women. Early differentiated thyroid cancer has a good prognosis, and surgery is the main treatment. Traditional open surgery would leave a scar on the neck. However, emerging minimally invasive procedures can avoid the scar on the neck, resulting in better aesthetic effect, which would have an impact on the quality of life of patients to a certain degree. This study intend to follow up patients regularly with early differentiated thyroid cancer undergoing different surgery. The quality of life, voice, scar would be assessed by authoritative questionaires or scales. We hope to demonstrate that minimally invasive surgery is better than traditional open surgery in order to provide reliable evidence for clinical practice.
The incidence of thyroid cancer has increased rapidly in recent years, especially in women. Differentiated thyroid cancer takes the largest proportion in thyroid cancer, but it has a good prognosis. For early differentiated thyroid cancer, surgery is the main treatment. Traditional open surgery would leave a scar on the neck, which is especially troublesome for female patients. However, emerging minimally invasive procedures, such as endoscopy-assisted subclavian approach, robot-assisted transaxillary or transoral approach, etc., can avoid the scar on the neck, resulting in better aesthetic effect, which would have an impact on the quality of life of patients to a certain degree. This study intend to follow up patients regularly with early differentiated thyroid cancer undergoing surgery according to a prospective cohort design. The evaluation questionnaires including quality of life, voice and scar would be completed to demonstrate that minimally invasive surgery is better than traditional open surgery not only in the way of effectiveness, but also in the quality of life. We hope to provide reliable evidence for clinical practice by this study.
Study Type
OBSERVATIONAL
Enrollment
230
different minimally invasive approach to complete thyroidectomy, including endoscopy-assisted subclavian approach, robot-assisted transaxillary or transoral approach (not leaving scar on the neck)
Conventional Open Surgery
Sun Yat-sen Memorial Hopsital
Guangzhou, Guangdong, China
RECRUITINGchange of quality of life (SF-36)
change of the scores of the SF-36(36-item Short-Form)questionaire
Time frame: baseline, 1month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
change of quality of life (Thyca-Qol)
change of the scores of the Thyca-Qol(Thyroid Cancer-specific Quality of Life) questionaire
Time frame: baseline, 1month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
voice handicap index
assessment of quality of voice
Time frame: baseline, 1 month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
scores of the surgical scar
scores of the questionaires (POSAS) about scar
Time frame: 1 month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
level of thyroglobulin
an indicator to monitor tumor residual or recurrence
Time frame: baseline, 1 month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
level of calcium
to indicate whether the patient have hypocalcemia
Time frame: baseline, 1 month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
operation duration
time for operation
Time frame: Intraoperative
blood loss
blood loss during operation
Time frame: up to 1 week after surgery
postoperative drainage
drainage volume after surgery
Time frame: up to 1 week after surgery
complications
complication events after surgery, e.g. hoarseness, hypocalcemia, hemorrhage, seroma
Time frame: baseline, 1 month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
satisfaction of the surgery
Visual Analog Score for satisfaction
Time frame: 1 month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
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