Immediate Implant Placement Using Volume-Stable Collagen Matrix Combined With rhPDGF-BB

Inclusion Criteria: * Age 18-95 * Has a single hopeless tooth in the maxillary esthetic zone (i.e., first premolar to first premolar, tooth #5-tooth #13) * Adequate oral hygiene (i.e., full-mouth bleeding score (FMBS) and full mouth plaque score (FMPS) of less than 25%) * Adequate tooth space to support an immediate implant placement (i.e., adequate mesiodistal space of greater than or equal to 6 mm and interocclusal space to support a non-occluding provisionalization). * Postextraction vertical bone defect of the buccal socket wall was less than or equal to 3mm Exclusion Criteria: * patients taking long-term (more than 3 months) medications affecting bone metabolism * generalized untreated periodontitis with greater than of 30% of sites with greater than 5mm pocket depths and bleeding upon probing with a dental probe * medical contraindications for having a surgical procedure (i.e., ASA Status of III, patient with a severe systemic disease that is not life-threatening; ASA Status of IV, a patient with a severe systemic disease that is a constant threat to life). * history of radiotherapy in the head and neck region * heavy smoker (greater than 10 cigarettes per day) * pregnancy * gingival recession before extraction in relation to the contralateral tooth