Prospective Evaluation of AI R&D Tool in Adult Glioma and Other Primary Brain Tumours (PEAR-GLIO)

Inclusion: 1. Patient diagnosed with operable brain cancer, thought likely to be primary solid brain tumor on imaging (grade 2 - 3 meningioma; grade 1 - 4 tumors otherwise) or with histologically proven primary malignant solid brain tumor 2. Able to give written informed consent prior to admission to this study; 3. Female or male aged ≥18 years; 4. Patient consents to the use of their surgical sample and 40mL of whole blood for research purposes 5. Surgical sample and yields ≥0.4g for the study 6. Patient consents to providing histopathology data (e.g., confirmation of histological subtype as oligodendroglioma) and other pseudonymised health information including imaging, treatment and outcome data. Exclusion: 1. Inoperable or biopsy only 2. Suspected lymphoma or myeloma, or grade 1 meningioma 3. Preoperative haemoglobin levels below 120g/L 4. Patients who have already received chemotherapy, targeted therapy, immunotherapy, or radiotherapy less than 30 days before date of surgery, unless as part of a clinical trial (requires per-patient sponsor approval) 5. Recurrence of cancer originating from a site other than the brain 6. Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that, in the investigator's opinion, gives reasonable suspicion of a disease or condition that may affect the interpretation of the results, render the patient at high risk from treatment complications or interferes with obtaining informed consent.