Bolus vs. Continuous IV Lidocaine Against Post-Extubation Cough in Post-Thyroidectomy Patients

Universitas Padjadjaran40 enrolled

Overview

The goal of this randomized controlled trial is to compare the effect of lidocaine bolus intravenous administration to lidocaine continuous intravenous administration in post thyroidectomy patients to observe the effect against post-extubation cough. The main questions it aims to answer are: * Cough incidence on both groups * Which method is preferable to reduce post-extubation cough incidence

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Cough

Interventions

Lidocaine IVDRUG

Lidocaine given as bolus or continuous infusion.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA class 1 and 2 * Thyroidectomy patients in Hasan Sadikin Bandung Hospital Exclusion Criteria: * Subjects' refusal * Had history of drug allergy, specifically lidaocaine * Had history of asthma or other lung diseases * Active smoker * History of arrhythmia * Bradycardia subjects (\<60 beats per minute) * Pregnant people * Perioperative upper respiratory tract infusion * Routinely consume ACE inhibitor / bronchodilators / steroid * Renal dysfunction * Liver dysfunction

Locations (1)

Hasan Sadikin General Hospital

Bandung, West Java, Indonesia

Outcomes

Primary Outcomes

Post-Extubation Cough Grade

Cough graded according to the following criteria: Grade 0: no cough; Grade 1: mild, only 1 cough; Grade 2: moderate, \>1 cough lasting \<5 seconds; Grade 3: coughing heavily and continuously for \>5 seconds)

Time frame: 24 hours post operative

Secondary Outcomes

Number of participant experiencing tachycardia

Tachycardia is defined as heart rate \>100 beats per minute

Time frame: 24 hours perioperative

Number of participant experiencing bradycardia

Bradycardia is defined as heart rate \<60 beats per minute

Time frame: 24 hours perioperative

Number of participant experiencing hypertension

Increase of blood pressure \>20% from initial blood pressure

Time frame: 24 hours perioperative

Number of participant experiencing hypotension

Decrease of blood pressure \<20% from initial blood pressure

Time frame: 24 hours perioperative

Data from ClinicalTrials.gov

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