The goal of this randomized controlled trial is to compare the effect of preemptive ketamine administration to placebo administration in patients underwent hysterectomy surgery. The main questions it aims to answer are: 1. To determine the effect of ketamine at a dose of 0.5 mg/kgBW as preemptive analgesia on the duration of analgesia after hysterectomy surgery 2. To determine the effect of ketamine at a dose of 0.5 mg/kgBW as preemptive analgesia on the need for fentanyl after hysterectomy surgery
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
40
The intervention was prepared by the research team (anesthesia resident) in the form of ketamine which had been diluted to a dosage of 10 mg/cc, taken according to the required dose based on actual body weight then diluted with 0.9% NaCl to 10 cc. Then the two solutions were given to researchers without knowing the contents of the drugs that had been prepared by the resident who assisted in this research.
While the 0.9% NaCl solution was used as placebo was prepared in a 10 cc syringe
Universitas Padjadjaran
Bandung, West Java, Indonesia
Duration of postoperative analgesia
Time interval from completion of hysterectomy until additional analgesic is needed, namely fentanyl 25 µg via PCA
Time frame: 24 hours post operative
Total need for post-operative analgesic rescue
The total amount of rescue analgetic required by research subjects, during the 24 hours after surgery, was given via PCA
Time frame: 24 hours post operative
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