Pilot Study: Oral Treatment of American Tegumentary Leishmaniasis (Cutaneous and Mucosal Forms) in the Elderly

Inclusion Criteria: * Active confirmed cutaneous leishmaniasis ou mucosal leishmaniasis * Use of highly effective contraceptive method and a negative serologic pregnancy test (beta - HCG), if female in fertile phase * Agree and sing informed consent form Exclusion Criteria: * Previous treatment with leishmanicidal drugs in the last 6 months * Pre-treatment electrocardiographic changes that contraindicate the use of liposomal amphotericin B (QTc greater than 450ms) * Serum creatinine or urea 1.5 times the upper limit of normal * Patients with severe or decompensated liver, kidney, heart disease, Diabetes Mellitus * history of any hypersensitivity reaction to liposomal amphotericin B, miltefosine and/or pentoxifylline * Pregnant and breastfeeding women * Patients with Acquired Immunodeficiency Syndrome (AIDS) or other immunodeficiency