Bone and Inflammatory Outcomes - Nutrition and Exercise Trials

York University20 enrolled

Overview

This study investigates whether dairy products will positively impact loading exercise-induced bone turnover and bone cell activity and/or the post-exercise inflammatory response in healthy young adults compared to a carbohydrate drink and/or water.

Introduction: Two million individuals at a cost of around 4.6 billion dollars a year in Canada suffer from osteoporosis. It is important to investigate strategies that can reduce bone loss and/or increase bone mass. Similarly, inflammation is associated with many different disease states, and investigating strategies to reduce systemic inflammation is prudent. Nutrition and exercise may be inexpensive and accessible strategies to improve bone health and inflammation and should be explored in different contexts and implemented. Our proposed research combines both nutrition and exercise along with the assessment of bone turnover and inflammatory markers in healthy young adults. Design: Randomized controlled crossover trial Participants: Healthy, university aged males and females. Methods: During the study participants will complete 4 different acute exercise and nutritional supplement trials, in random order. The four trials are: 1) exercise+carbohydrate (CHO), 2) exercise+milk (Milk), 3) exercise+Greek yogurt (GY), and 4) exercise+water (W). The whole study will take a maximum of 16 weeks and each supplement trial will be separated by 2-4 weeks. Outcomes: several markers of bone turnover and bone cell activity as well as markers of inflammation will be measured in the blood, before exercise and at different times post-exercise and post supplement consumption.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy Bone Inflammation

Interventions

High-Intensity ExerciseBEHAVIORAL

A single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial.

Carbohydrate (Maltodextrin powder mixed with water)DIETARY_SUPPLEMENT

50g consumed immediately after exercise and 1h after exercise.

Skim MilkDIETARY_SUPPLEMENT

500ml consumed immediately after exercise and 1h after exercise.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Between the ages of 18-30 years * Normal BMI (18.5-24.9) kg/m\^2 * Low to moderately physically active (0-2 times/week) * No allergy to dairy protein or lactose intolerance * On no medication related to a chronic condition * On birth control or naturally cycling with a regular menstrual cycle) Exclusion Criteria: * Regular smoker (cigarettes, e-cigarettes (e.g., vapes) or cannabis) * Any chronic condition, inflammatory, or auto-immune condition

Locations (1)

York University

Toronto, Ontario, Canada