AM vs PM Exercise Training

Michigan State University79 enrolled

Overview

The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with the body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise training performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.

Blood pressure has an internal rhythm associated with the 24-hr clock. Nocturnal blood pressure (BP) is a key contributor to cardiovascular health and may be improved by exercise. Moreover, the time of day of the exercise may be a key factor. This study aims to evaluate the effects of morning and evening exercise training on BP and other measures of vascular function in older females with hypertension.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Hypertension

Eligibility

Sex: FEMALEMin age: 55 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Systolic BP equal to or greater than 130 mmHg without BP medication or greater than 120 mmHg with medication and diastolic blood pressure equal to and greater than 80 mmHg * 55-80 years old * Post-menopausal female * Able to walk without assistance Exclusion Criteria: * Habitually physically active defined as 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week * Overt pulmonary disease/condition as follows: chronic bronchitis, chronic obstructive pulmonary disease, emphysema, or pulmonary hypertension * Cardiometabolic disease/condition as follows: diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, renal disease, secondary hypertension, chronic venous insufficiency or deep vein thrombosis within last 6 months * Cancer within last 5 years * Body mass index \>39 kg/m2 * Current smoking or vape * Evening shift work * uncontrolled thyroid disorder * 2 or more falls in the last year * Anemia within 3 months of enrollment * Parkinson's disease * Dementia * Unstable angina * Acute pulmonary embolus or infarction * Acute myocarditis or pericarditis * Acute aortic dissection

Outcomes

Primary Outcomes

Nocturnal systolic blood pressure (BP)

Change in systolic nocturnal BP (Pre-training - Post-training)

Time frame: 6 weeks

Secondary Outcomes

Endothelial function

Change in flow mediated dilation of the brachial artery (Post-training - Pre-training)

Time frame: 6 weeks

Microvascular function

Change in rapid onset vasodilation of the popliteal artery

Time frame: 6 weeks

Ambulatory blood pressure

Change in systolic and diastolic BPs over a 24-hr period (Pre-training - Post-training)

Time frame: 6 weeks

Arterial stiffness

Change in carotid femoral pulse wave velocity (Pre-training - Post-training)

Time frame: 6 weeks

AM vs PM Exercise Training

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts