Revitalization of Traumatized Immature Permanent Teeth

Universitaire Ziekenhuizen KU Leuven72 enrolled

Overview

This study aims to assess the hypothesis that revitalization of teeth without (a)symptomatic apical periodontitis have a more favourable outcome in terms of further root development, periapical bone healing, maintaining/regaining pulp sensitivity and survival, than teeth with (a)symptomatic apical periodontitis.

1. Trial objectives This study aims to investigate the effectiveness of revitalization procedures, in terms of maintaining or restoring periapical health, further root development and regaining of pulp sensitivity, in immature permanent teeth with (group 1) or without (group 2) (a)symptomatic apical periodontitis . 2. Primary endpoints RRA at 1 year post revitalization. 3 Secondary endpoints Maintained or restored periapical health (evaluated within each group separately due to expected baseline inequivalency between groups) 1 year post revitalization. 4 Other endpoints * RRA 2 and 3 years post revitalization * Maintained or restored periapical health 2 and 3 years post revitalization (evaluated within each group separately) * Pulp sensitivity 1-3 years post revitalization (evaluated within each group separately due to expected baseline inequivalency between groups) * Tooth survival 3 years post revitalization (even if no further root development and incomplete periapical bone healing with no clinical symptoms). 5 Trial Design Open, prospective cohort, multicenter Blinded: radiographic assessment and statistical analysis; operators and patients cannot be blinded, due to practically not feasible.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Apical Periodontitis Trauma

Interventions

revitalizationOTHER

The main idea behind revitalization is to firstly disinfect the root canal and subsequently attract or transplant mesenchymal stem cells from the (remaining) dental pulp and apical papilla (in case of immature permanent teeth) into the root canal. More specifically, this therapy is not based on mechanical and (aggressive) chemical debridement as in conventional root canal treatment but is supported by the pillars of tissue engineering: stem cells, growth factors and a scaffold .

Eligibility

Sex: ALLMin age: 6 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Provision of Informed Consent * Female and male patients * Age range: 6-18 years * "Healthy": ASA I and II * Permanent immature tooth (Cvek stage of root maturation ≤ 2) requiring revitalization * Etiological factor: (a)symptomatic apical periodontitis post dental trauma or irreversible pulpitis post dental trauma Exclusion Criteria: * Unlikely to be able to comply with the study procedures, as judged by the investigator * Patients older than 18 years and younger than 6 * Deciduous teeth * Cvek root maturation stage \> 2: permanent immature tooth that can be treated by conventional root canal treatment or apexification * Known or suspected current malignancy * History of chemotherapy within 5 years prior to study * History of radiation in the head and neck region * History of other metabolic bone diseases * Bleeding disorders * Involvement in the planning and conduct of the study

Locations (1)

Ghent University

Ghent, Belgium

RECRUITING

Outcomes

Primary Outcomes

radiographic root area (RRA)

RRA post revitalization

Time frame: 1 year

Secondary Outcomes

periapical health

Maintained or restored periapical health post revitalization

Time frame: 1 year

Central Contacts

Nastaran Meschi, MSc, PhD

CONTACT

+32476313889 nastaran.meschi@ugent.be

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.