Study on Doppler Ultrasound Measurement of Changes in Uterine Artery Blood Flow in Normal First Trimester Pregnancies and Its Prediction on Abortion

N/ANot Yet RecruitingNCT06043804

Second Affiliated Hospital of Wenzhou Medical University200 enrolled

Overview

Objective:To explore the study of Doppler ultrasound in first trimester pregnancies to measure the change of uterine artery blood flow in normal pregnancies and the prediction on abortion, which provides a certain reference for the change trend of uterine artery blood flow in normal first trimester pregnancies and the prediction of Doppler ultrasound measurement in abortion. Method:Pregnant women who underwent natural conception and single birth prenatal examination in the Obstetrics Department of the Second Affiliated Hospital of Wenzhou Medical University from October 1, 2023 to December 31, 2025 were selected as the study population. Eligible women were preliminarily screened according to the inclusion conditions of the study objects, and basic information of women in each group was compared: Maternal age, gestational time, birth time, gestational week, abortion history, maternal BMI, maternal MAP, smoking status, serum HCG, subchorionic hematoma, fetal bradycardia, left and right uterine aorta pulse index (PI), resistance index (RI) and systolic/diastolic ratio (S/D), etc. To investigate the effect of Doppler ultrasonography on the measurement of uterine artery blood flow in normal pregnancy and the prediction of abortion.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Abnormal Uteroplacental Circulation

Interventions

Eligibility

Sex: FEMALEMin age: 16 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Healthy pregnant women Group Inclusion Criteria: 1. Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks; 2. Complete maternal clinical data; Exclusion Criteria: 1. The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography; 2. multiple pregnancy; 3. Patients with congenital uterine malformations, uterine fibroids and any other uterine disease; 4. Patients who have chronic diseases or are receiving chronic treatment. Pregnant women with recurrent pregnancy loss Group Inclusion Criteria: 1. Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks; 2. Complete maternal clinical data; 3. There has been a history of spontaneous abortion with the same sexual partner for two or more consecutive times; Exclusion Criteria: 1. The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography; 2. multiple pregnancy; 3. Patients with congenital uterine malformations, uterine fibroids and any other uterine disease; 4. Patients who have chronic diseases or are receiving chronic treatment.

Outcomes

Primary Outcomes

Pulsatility index

Pulsatility index of the left and right main uterine arteries

Time frame: it can be monitored for up to 12 weeks

Resistive index

Resistive index of the left and right main uterine arteries

Time frame: it can be monitored for up to 12 weeks

Systolic-to-diastolic ratio

Systolic-to-diastolic ratio of the left and right main uterine arteries

Time frame: it can be monitored for up to 12 weeks