The goal of this interventional study is to learn about the effects of different proteins (from animals or plants) on the metabolism in healthy, normal weight women between 18-45 year who are not on hormonal birth-control. The main questions the study aims to answer are: 1. How do different proteins affect biological markers of the metabolism and which protein has the strongest effect? 2. How are the different proteins digested and taken up from our body? Participants will drink four different shakes on four different study days in a random order. Three of them contain each a different protein and one does not contain protein. Right before drinking the shake and on 11 timepoints after drinking the shake blood samples will be drawn.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
28
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Participants will consume the placebo in an opaque mug wearing a nose clip.
Örebro University
Örebro, Sweden
Release of Growth Hormone
The primary outcome is defined as the postprandial release of growth hormone during three hours after oral ingestion of plant-protein test drinks vs. an animal-protein test drink measured as incremental area under the curve. Growth hormone will be measured in blood samples.
Time frame: 0-3 hours after consumption of test drink (on all 4 study days)
Release of Hormones Related to the Somatotrophic Axis
We will measure different hormones related to the somatotrophin axis in collected blood samples and investigate if there are differences between different protein-sources.
Time frame: 0-3 hours after consumption of test drink (on all 4 study days)
Kinetics of Amino Acid Uptake
We will measure amino acids in collected blood samples to investigate dynamics and kinetics of protein digestion/uptake of different protein sources.
Time frame: 0-3 hours after consumption of test drink (on all 4 study days)
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