This study was an ambispective observational cohort study that included sepsis patients hospitalized in the Intensive care unit (ICU) of the Nankai Hospital. All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.
All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.
Study Type
OBSERVATIONAL
Enrollment
150
disease
Tianjin Nankai Hospital
Tianjin, Tianjin Municipality, China
RECRUITINGcAMP-response element binding protein 3, CREB3
CREB3 levels were measured in the PBMCs of sepsis patients and healthy controls
Time frame: Up to Day 28
ADP-ribosylation factor 4, ARF4
ARF4 levels were measured in the PBMCs of sepsis patients and healthy controls
Time frame: Up to Day 28
Heme oxygnase-1, HO-1
HO-1 levels were measured in the PBMCs of sepsis patients and healthy controls
Time frame: Up to Day 28
ARF family
ARF1, ARF3, ARF5, ARF6 levels were measured in the PBMCs of sepsis patients and healthy controls
Time frame: Up to Day 28
Oxygenation index
The ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen (FiO2 expressed as a fraction, not a percentage).
Time frame: Up to Day 28
Mechanical ventilation days
The number of days the patient was alive and mechanical ventilating
Time frame: Up to Day 28
Inflammation biomarkers Inflammation levels
Procalcitonin (PCT), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6)
Time frame: Up to Day 28
ICU stay length
The number of days the patient was alive and ICU stay
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Time frame: Up to Day 90
28 days survive
All Cause Mortality to Day 28
Time frame: Up to Day 28
Sequential Organ-Failure Assessment (SOFA) score
The SOFA score is used to assess the severity and prognosis of sepsis. SOFA was based on six different scores, one for each of the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems each scored from 0 to 4 with an increasing score reflecting worsening organ dysfunction.
Time frame: Up to Day 28
Acute Physiology and Chronic Health Evaluation II (APACHE II) score
The APACHE II score consists of three parts: acute physiological score, age score, and chronic health score. APACHE II uses a point score (range 0 to 71) based upon initial values of 12 routine physiologic measurements, age, and previous health status to provide a general measure of severity of disease, with an increasing score reflecting worsening organ dysfunction.
Time frame: Up to Day 28