The goal of this clinical trial is to evaluate effects of consecutive Yellow and Red Light Emitting Diode photobiomodulation in dry age-related macular degeneration (AMD). The main questions it aims to answer are: * Is Yellow and Red Light Emitting Diode photobiomodulation effective in decreasing drusen volume in patients affected by dry AMD? * Does Yellow and Red Light Emitting Diode photobiomodulation increase visual acuity and contrast sensitivity in patients affected by dry AMD? Participants will be randomly assigned to a treatment or a sham group. Treatment consists in two cycles with two phases each: * 1st phase: 300 seconds of continuous Yellow light with eyes closed + 60 seconds of pulsed Yellow light with eyes opened; * 2d phase: 300 seconds of continuous Red light with eyes closed + 60 seconds of pulsed Red light with eyes opened. Cycle 1 consists of 8 sessions (two PBM per week for 4 weeks) and cycle 2 consists of 6 sessions (two PBM per week for 3 weeks). Researchers will compare patients in the treatment group to those in the sham group to evaluate differences in objective signs and subjective symptoms of dry AMD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
180
Each session consists of: * 1st phase: 300 seconds of continuous Yellow light (eyes closed) + 60 seconds of pulsed Yellow light (eyes opened) * 2nd phase: 300 seconds of continuous Red light(eyes closed) + 60 seconds of pulsed Red light (eyes opened). Cycle 1: 8 sessions (two PBM per week for 4 weeks); Cycle 2: 6 sessions (two PBM per week for 3 weeks).
Low light emission mask (Sham Mask, Espansione group, Bologna, Italy)
University of Paris
Paris, France
RECRUITINGUniversità degli Studi di Ferrara
Ferrara, Italy
RECRUITINGUniversità degli studi della Campania Luigi Vanvitelli
Napoli, Italy
RECRUITINGUniversità di Torino
Torino, Italy
RECRUITINGUniversity of Ankara
Ankara, Turkey (Türkiye)
RECRUITINGKoç University Hospital
Koç, Turkey (Türkiye)
RECRUITINGEarlam and Christopher
Taunton, United Kingdom
RECRUITINGBest Corrected Visual Acuity variation
ETDRS letters
Time frame: 1 month, 2 months and 4 months after each cycle
Drusen Volume Variation
Based on SD-OCT Heidelberg
Time frame: 1 month, 2 months and 4 months after each cycle
Contrast sensitivity variation
Based on Pelli Robson chart
Time frame: 1 month, 2 months and 4 months after each cycle
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