Comparison of 3 in Vivo Microscopic Imaging Techniques for the Diagnosis of Pigmented Tumors

Centre Hospitalier Universitaire de Saint Etienne161 enrolled

Overview

Reflectance confocal microscopy (RCM) is the reference in vivo imaging technique for identifying malignant melanocytic tumors prior to surgical excision. However, it is not widely used due to its high cost and highly technical and time-consuming nature. In addition to Reflectance confocal microscopy (RCM), it currently use 2 less expensive dermatoscopes that also allow in vivo diagnosis: super-high magnification dermoscopy (D400) and Fluorescence-Advanced videodermatoscopy (FAV).

Several studies have demonstrated their interest in the in vivo diagnosis of melanocytic tumors, but without any comparison between these methods. In our current practice, many patients have benefited from these 3 imaging modalities for benign and malignant lesions. Therefore, our aim is to analyze these images and compare their performance in the diagnosis of benign and malignant pigmented lesions.

Study Type

OBSERVATIONAL

Enrollment

161

Conditions

Basal Cell Carcinoma Lentigo Maligna Melanoma Nevus Seborrheic Keratosis Lentigo

Interventions

Fluorescence-Advanced videodermatoscopyDIAGNOSTIC_TEST

Datas collected : Presence or absence of atypical roundish cell, dendritic cell, atypical nests, points, folliculotropism, blue homogenous zone, regular honeycomb pattern. Between 10 and 60 images taken by a hand-held camera set directly on the skin lesion, with an oily interface.

Reflectance confocal microscopyDIAGNOSTIC_TEST

Super-high magnification dermoscopyDIAGNOSTIC_TEST

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with a pigmented skin lesion of more than 3mm diameter which have benefited systematically of all 3 imaging techniques at the same time, followed by either a surgical excision or annual imaging monitoring. Exclusion Criteria: * Bad quality images * Insufficient number of images * Uncertain diagnosis given by the pathologist * Refusal

Outcomes

Primary Outcomes

To compare the the relevance of each technique for the diagnostic of pigmented lesions.

The nature of the tumor is diagnosed by the imaging technique.

Time frame: Day 1

Secondary Outcomes

Comparison of performance of imaging techniques

Analyze the results of imaging of each technique.