The investigators collected clinical data and serum samples of patients with polycystic ovary syndrome (PCOS) in this study, used statistical software such as SPSS for date analysis, and used experimental techniques such as ELISA and flow cytometry to detect serum samples, aiming to explore the relationship between the body anthropometry, skin conditions, psychosomatic status, diet, sleep, exercise, glucose and lipid metabolism, gonadal hormones, and body fat distribution in patients with polycystic ovary syndrome, and to discovery new biomarkers. Multidisciplinary exploration of the mechanisms of disease occurrence and development, the establishment of a PCOS multicenter, multidisciplinary and multidimensional clinical research database, combined with the established statistical analysis strategy for big data and analysis, to promote the realization of more accurate personalized medicine.
Study Type
OBSERVATIONAL
Enrollment
3,000
This study does not involve any interventions
Department of Endocrinology, Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGFibrinogen-like-protein 1 (FGL1)
Fibrinogen-like-protein 1 (FGL1), is a novel hepatokine that plays an important role in hepatic steatosis, insulin resistance and obesity. There is no maximum or minimum value for this parameter and the higher scores mean a worse outcome.
Time frame: baseline
body mass index ,BMI
BMI=weight(kg)/height(m)\^2
Time frame: baseline
Waist/hip Ratio,WHR
WHR=Waist Circumference(cm)/Hip Circumference(cm)
Time frame: baseline
Number of menstruation in the last year
physiological parameter,the total number of menstrual periods in the last year
Time frame: baseline
Ferriman-Gallwey score
The minimum value of Ferriman-Gallwey score is 0 and the maximum value is 44. An Ferriman-Gallwey score greater than or equal to 6 is considered to be a clinical manifestation of androgen excess.
Time frame: Time Frame: baseline
HOMA-IR
Homeostatic model assessment insulin resistance index
Time frame: baseline
TT
total testosterone (nmol/L)
Time frame: baseline
FT
Free testosterone (nmol/L)
Time frame: baseline
LH
luteinizing hormone
Time frame: baseline
FSH
follicle-stimulating hormone
Time frame: baseline
FBG
fasting blood-glucose
Time frame: baseline
PBG
postprandial blood-glucose
Time frame: baseline
FINS
fasting serum insulin
Time frame: baseline
PINS
postprandial serum insulin
Time frame: baseline
AST
aspartate aminotransferase
Time frame: baseline
ALT
alanine aminotransferase
Time frame: baseline
UA
Uric acid
Time frame: baseline
CR
Creatinine
Time frame: baseline
LDL-c
low-density lipoprotein cholesterol
Time frame: baseline
HDL-c
high-density lipoprotein cholesterol
Time frame: baseline
TC
Total Cholesterol (mmol/L)
Time frame: baseline
TG
Triglyceride (mmol/L)
Time frame: baseline
Interleukin 22#IL-22
The factor reflects that the organism is in an inflammatory state. There is no maximum or minimum value for the factor and the higher scores mean a worse outcome.
Time frame: baseline
Interleukin 6#IL-6
IL-6. The factor reflects that the organism is in an inflammatory state. There is no maximum or minimum value for the factor and the higher scores mean a worse outcome.
Time frame: baseline
Interleukin 8# IL-8
The factor reflects that the organism is in an inflammatory state. There is no maximum or minimum value for the factor and the higher scores mean a worse outcome.
Time frame: baseline
Tumor Necrosis Factor# TNF
The factor reflects that the organism is in an inflammatory state. There is no maximum or minimum value for the factor and the higher scores mean a worse outcome.
Time frame: baseline
Chemerin
A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function.
Time frame: baseline
omentin-1
A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function.
Time frame: baseline
leptin
A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function.
Time frame: baseline
RBP-4
A adipocytokine.The factor is expressed in adipose tissue and is related to specific adipose tissue function.
Time frame: baseline
adiponectin
A adipocytokine. The factor is expressed in adipose tissue and is related to specific adipose tissue function.
Time frame: baseline
DHEAS
dehydroepiandrosterone（nmol/L）
Time frame: baseline
SHBG
sex hormone-binding globulin (nmol/L)
Time frame: baseline
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