Endurance Training in Patients With Post-TB Lung Disease

Riphah International University36 enrolled

Overview

To determine the effects of endurance training on functional capacity and QOL(Quality of life) in patients with post-TB (tuberculosis) lung disease. Post-tuberculosis lung disease is a major health concern nowadays. There is limited evidence in the literature regarding the rehabilitation of patients with cured tuberculosis which leads to post-TB complications.

Adults with post-TB respiratory symptoms experience skeletal muscle weakness due to inactivity, systemic inflammation, and poor nutrition, which is frequently made worse by poverty. Such patients experience a vicious cycle that includes decreased body weight, increasing morbidity, and higher mortality. People with Chronic Respiratory Diseases frequently avoid exercise, which causes them to lose motivation and decondition. This cycle of decline continues. In Pakistan, there is no concept of pulmonary rehabilitation for TB patients. The current study will attempt to fill this literature gap and also promote the concept of pulmonary rehabilitation for post-tuberculosis patients in Pakistan.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Tuberculosis Post-Tuberculous Pleural Fibrosis Post-Tuberculous Bronchiectasis

Interventions

ExperimentalOTHER

Cycling 2 days per week with Borg dyspnea 4-6 level for 15-20 minutes/ day with 5 minutes warm-up and cool-down. Strengthening exercises for upper limb muscles (pull-ups and biceps curls) and for lower limb muscles (sit-to-stand and step-up exercises) with 3 sets of 8-12 repetitions \* 2 days per week. Pursed Lip breathing exercise 3 sets of 5-10 repetitions for 6 weeks

ControlOTHER

Usual care: frontal chest radiographs, verbal advice to quit smoking, and reduce exposure to biomass smoke. Spirometry to screen for airway diseases. Antibiotic and systemic glucocorticoid therapy.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * TB (diagnosed) with Completed TB course * Dyspnea (with or without cough) * Age (18-50yrs). * After 3 months of AFB and gene expert (-) * Decreased PFT predicted values Exclusion Criteria: * Smoker, Diabetes, and cardiac patients * Physical disabled, pregnant (lactating women) * Sputum + testing for TB * Gene expert * CVD (unstable) * Not willing to participate

Locations (1)

Green Star NGO

Peshawar, KPK, Pakistan

Outcomes

Primary Outcomes

Functional capacity

Changes from baseline to 3 weeks and 6 weeks after the intervention, measured through 6 min walk test (6 MWT). It is a submaximal exercise test that can aid in assessing the functional capacity of patients with cardiopulmonary diseases, in this test we find out the maximum distance in meters that an individual covers in 6 min without any support.

Time frame: 3 weeks, 6 weeks

Dyspnea

Changes from baseline to 3 weeks and 6 weeks after the intervention, measured through the BORG dyspnea scale. it uses a scale from 0 to 10, where 0 represents no dyspnea and 10 represents maximal dyspnea.

Time frame: 3 weeks, 6 weeks

Forced Expiratory Volume in 1 second (FEV1)

Changes from the Baseline, the digital spirometer is used in the clinical setting to analyze Forced Expiratory Volume in 1 second FEV1 in Liters

Time frame: 3 weeks,6 weeks

Forced vital Capacity (FVC)

Changes From the Baseline, the digital spirometer is used in clinical setting to analyze Forced vital Capacity in Liters

Time frame: 3 weeks,6 weeks

Peak Expiratory Flow (PEF)

Changes from the Baseline, the digital spirometer is used in clinical setting to analyze peak expiratory flow PEF in Liter/second.

Time frame: 3 weeks,6 weeks

Data from ClinicalTrials.gov

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