The scientific literature has verified that coconut oil has properties that open perspectives for its application in order to maintain oral health and, in particular, for the treatment of different oral pathologies. Thus, the purpose of this project is summarized in the following objectives: 1. Determine in vitro the biocompatibility of coconut oil. 2. Determine in vivo the clinical effect of coconut oil as an adjunct treatment for periodontal disease.
Periodontal disease is one of the most prevalent pathologies in humans. In the latest survey on Oral Health in Spain by the Council of Dentists of Spain, it is determined that between 85-94% of the Spanish population over 35 years of age has some problem related to their gums. Severe periodontal diseases, which can lead to tooth loss, affect 15%-20% of middle-aged adults (35-44 years). One of the most common products used as an antibacterial agent to treat different oral conditions is chlorhexidine and its derivatives. Chlorhexidine exists commercially in different preparations such as mouthwash, toothpaste and gel, among others. Their main drawbacks are that in the long term they stain the teeth and can cause oral lesions, burning sensation and a deterioration in the sensation of taste. Likewise, various antibiotics, both local and systemic, are used as an adjuvant in the treatment of certain types of gum diseases. Due to the rapid increase in bacterial resistance due to the extensive use of antibiotics, it is important to evaluate alternative antimicrobial agents that can help reduce the use of antibiotics. Both the coconut and the plant from which this fruit comes are widely used in traditional medicine. Furthermore, the scientific literature on the biological effect of different presentations of this plant (alcoholic extract of coconut shell, coconut water, coconut oil, etc.) has shown, among others, anti-inflammatory activities, analgesic, antioxidant, antifungal, antimicrobial and even antitumor. There are several hypotheses that suggest that the benefits of using coconut oil can be attributed to the presence of lauric acid, which has the ability to destroy the lipid membrane of microorganisms such as the herpes virus and Gram positive and Gram negative bacteria. Likewise, the viscosity of the oil could inhibit bacterial adhesion and plaque accumulation. Recent studies describe that oral rinses with coconut oil provide an inhibition in the accumulation of bacterial plaque and plaque-induced gingivitis and a significant reduction of Streptococcus mutans in saliva, suggesting that coconut oil can have a preventive therapeutic application, with fewer adverse effects and lower cost for the maintenance of oral health and treatment of various oral pathologies such as Gingivitis and Periodontitis. Therefore, the purpose of this study is to determine the effectiveness of coconut oil as an adjunct treatment for periodontal disease.
Coconut oil rinsing
Chlorhexidine rinsing
Control with water rinsing
Clinica Medico Dental Pardiñas
A Coruña, A Coruña, Spain
Probing depth in mm
To evaluate the effect of treatment on probing depth reduction.
Time frame: At 0 days, 30 days and 60 days
Bleeding on probing in percentage
To evaluate the effect of treatment on reduction of bleeding on probing
Time frame: At 0 days, 30 days and 60 days
Plaque index in percentage
To evaluate the effect of treatment on reduction of plaque accumulation
Time frame: At 0, 30 and 60 days
Volatile compounds in breath in ppm of sulphur compounds
To evaluate the effect of treatment on the presence of sulphur compounds present on breath
Time frame: At 0, 30 and 60 days
Type of bacteria present on samples from saliva and crevicular fluid using Illumina SBS (Sequencing by synthesis)
To evaluate the effect of treatment on the oral microbiome
Time frame: At 0, 30 and 60 days
Patient perception using Visual Analog Scale
To evaluate patient perception on the use of the mouthrinse in a scale from 1 to 10 for each question.
Time frame: At 0, 30 and 60 days
Tooth color change measured with the VITA score
To evaluate the change on tooth color before and after using the mouthwash.
Time frame: At 0, 30 and 60 days
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Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
30