MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach

Presence of distant metastasis (DM)

Clear clinical/radiographic evidence of distant metastases in the lung, bone, brain, liver or other distant sites.

Time frame: 5 years

Colostomy rate

The presence of a colostomy until colostomy removal.

Time frame: 5 years

Disease free survival (DFS)

The time from the date of registration to the date of first record of any of the following events including local, regional, distant failure, or death due to any cause.

Time frame: 5 years

Overall survival (OS)

The time from the date of registration to the date of death for any cause.

Time frame: 5 years

Physician-reported toxicities

Using the National Cancer Institute (NCI) Common Terminology Criteria of Adverse Events (CTCAE) V.5.

Time frame: 5 years

Patient Reported Outcomes

Using the Common Terminology Criteria of Adverse Events

Time frame: 5 years

Quality of life (QOL)

Based on the completion of the European Organisation For Research And Treatment Of Cancer (EORTC-C30) questionnaire. The EORTC-C30 questionnaire is a 30 item instrument meant to assess some of the different aspects that define the quality of life of cancer patients.

Time frame: 5 years

Quality of life (QOL)

Based on the completion of the European Organisation For Research And Treatment Of Cancer (EORTC-AN27) questionnaire. EORTC QLQ-ANL27 includes four quality of life domains: pain, bowel, sexual and stoma care problems and five single item (frequent urination, keeping clean, proximity to toilet, lower limb oedema, planning activities)

Time frame: 5 years