This phase 1b trial will evaluate the effects of EP262 in subjects with Chronic Inducible Urticaria (CIndU), including symptomatic dermographism and cold urticaria.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
33
Once daily
Advanced Clinical Research Institute
Tampa, Florida, United States
Treasure Valley Medical Research
Boise, Idaho, United States
Safety and tolerability of EP262
Assessed by the incidence of treatment-emergent adverse events
Time frame: Measured from Day 1 to End of Study or Early Termination (up to 12 weeks)
Change in Critical Friction Threshold (CFT)
Assessed by the number of prongs that elicit a wheal response using a FricTest (in subjects with symptomatic dermographism)
Time frame: Measured from Baseline to Week 4
Change in Critical Temperature Threshold (CTT)
Assessed as the highest temperature that elicits a wheal response using a TempTest (in subjects with cold urticaria)
Time frame: Measured from Baseline to Week 4
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Hanover, Lower Saxony, Germany
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