Metabolic Syndrome and Obstructive Sleep Apnea

Cairo University80 enrolled

Overview

Background:Metabolic syndrome is a disorder characterized by abdominal obesity,hypertension,increased triglycerides ,decreased HDL cholesterol and increased blood glucose. Accumulating evidence strongly indicates that insulin resistance and an increased amount of abdominal fat are the pathogenic factors for the characteristics of metabolic syndrome. Studies indicate that sleep apnea may be a manifestation of the metabolic syndrome. Subjects and methods:This study was conducted in the pulmonology department at kasrelainy hospital. It included 80 patients who came to the sleep lab unit for polysomnography. Each patient was subjected to full history taking including(sex,age,smoking history,presence of diabetes or hypertension),thorough clinical examination with emphasis on waist, neck\&hip circumference and blood pressure measurements,Laboratory investigations including :Lipid profile\& Diabetic profile(HBA1C).In addition to ESS and stop bang score questionnaire.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sleep Apnea Metabolic Syndrome

Interventions

sleep study

Eligibility

Sex: ALLMin age: 22 YearsMax age: 77 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients fulfilled the criteria of OSA ( obstructive sleep apnea) in the form of symptoms suggestive of OSA (daytime sleepiness/daytime fatigue/headache/snoring)and with AHI ( apnea-hyponea index) ≥5. Exclusion Criteria: 1. Cerebro-vascular accident within the preceding 30 days. 2. Patients on sedatives. 3. Patients on anti-psychotics

Outcomes

Primary Outcomes

Predictors of metabolic syndrome among OSA patients

evaluation of factors related to occurrence of metabolic syndrome in OSA such as age(in years),weight in kilograms(kg) and height in meters (m) will not be measured separately but combined to assess BMI( weight in kg/ height in m2) and oxygen saturation (O2%), evaluation of polysomnographic data and laboratory tests in the form of lipid profile in (mg/dl) and HBA1C (g/dl)

Time frame: 6 months