Prognostic Value of Tumor Deposits for Patients With Papillary Thyroid Carcinoma

Nanfang Hospital, Southern Medical University541 enrolled

Overview

Tumor deposits (TD), nodules in the peritumoral adipose tissue with no architectural residue of lymph node, which is a definition often being confusing to the extranodal extension (ENE), have been described in several malignancies and linked to a worse prognosis. In gastric cancer and colon cancer, TD and ENE should be distinguished and collected separately in 8th AJCC manual. However, in thyroid cancer, TD as a collection variable was absence in both the 8th AJCC manual and the 2015 ATA guideline. This is a study that revealed the presence of TD by reviewing a large number of papillary thyroid carcinoma (PTC) specimens and explored its prognostic value by constructing a nomogram to accurately predict disease-free survival in PTC patients.

Study Type

OBSERVATIONAL

Enrollment

541

Conditions

Exploring the Prognostic Value of Tumor Deposits PTC Patients

Interventions

surgeryPROCEDURE

if the patients is TD positive, we recommond careful surgery and pathological examination.

Medical Language ↔ Plain English

Inclusion Criteria: (1) patients with histopathologically confirmed PTC and sections stored in the pathology department; (2) patients underwent lobectomy or total thyroidectomy and central lymph node dissection with or without lateral neck dissection; (3) patients cooperated to provide follow-up information after surgery. Exclusion Criteria: (1) patients with previous history of neck irradiation or other systematic cancers; (2) patients died of unrelated diseases.

Outcomes

Primary Outcomes

disease-free survival (DFS) after diagnosis

The primary outcome was disease-free survival (DFS) after diagnosis, with endpoints as tumor locoregional recurrence, distant metastasis, and disease-specific death. If a patient was deceased, the cause of death was confirmed by the death certificate or the hospitalization record to identify disease-specific death.

Time frame: between 2015 and 2021

Secondary Outcomes

Disease recurrence

Disease recurrence was defined as recurrent or persistent PTC identified with standard biochemical, cytological, histological, and radiographical criteria. In this study, tumor locoregional recurrence was defined as combined biochemical (serum thyroglobulin) and structural recurrences.