The goal of this clinical trial is to test the safety and effectiveness of antiplatelet therapy in acute ischemic stroke (AIS) patients with thrombocytopenia. Participants will be prescribed antiplatelet agents and followed up for 3 months.
Antiplatelet therapy is widely used in non-cardiogenic AIS patients for secondary prevention. However, it may also increase the risk of bleeding complications, especially in patients with thrombocytopenia. The goal of this clinical trial is to test the safety and effectiveness of antiplatelet therapy in acute ischemic stroke (AIS) patients with thrombocytopenia. Participants will be prescribed antiplatelet agents and followed up for 3 months.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
1,200
Participants will be prescribed antiplatelet agents including aspirin, clopidogrel, cilostazol, and dipyridamole.
Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, China
RECRUITING90-day Composite events
Composite events including ischemic stroke, hemorrhagic stroke, myocardial infarction, major extracranial hemorrhage, and vascular death within 90 days after enrollment
Time frame: 90 days
90-day ischemic stroke
Ischemic stroke within 90 days after enrollment
Time frame: 90 days
90-day hemorrhagic stroke
Hemorrhagic stroke within 90 days after enrollment
Time frame: 90 days
90-day myocardial infarction
Myocardial infarction within 90 days after enrollment
Time frame: 90 days
90-day major extracranial hemorrhage
Major extracranial hemorrhage within 90 days after enrollment
Time frame: 90 days
90-day non-major bleeding
Non-major bleeding within 90 days after enrollment
Time frame: 90 days
90-day vascular death
Vascular death within 90 days after enrollment
Time frame: 90 days
90-day all-cause death
All-cause death within 90 days after enrollment
Time frame: 90 days
Discharge mRS
Modified Rankin scale at discharge
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Time frame: Through hospitalization, an average of 7 days