Clinical Study on 68Ga-PSMA-33 for PET/CT Imaging of Prostate Cancer

Inclusion Criteria: * Male sex * Age 18 years or older * Patients must have histologically or cytologically confirmed localized or metastatic prostate cancer * Creatinine less than or equal to 1.5 X upper limit of normal * ECOG performance status 0 - 2, inclusive * Able to tolerate the physical/logistical requirements of a PET/CT scan including lying supine (or prone) for up to 30 minutes and tolerating intravenous cannulation Patient with complete clinical data. * The effects of 68Ga-PSMA-33 on the developing human fetus at the recommended therapeutic dose are unknown. For this reason, men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. * Able to understand and provide written informed consent Exclusion Criteria: * Patient age \< 18 years * Received radioisotope diagnosis or treatment before enrollment, and the time window did not exceed 10 physical half-lives * Malignancy other than current disease under study * Patient simultaneously participating in another clinical trial * Patient who cannot stay on PET/CT * Patient with HIV, HCV, HVB infection or other serious chronic infection * Patient with liver and kidney function (GFR less than 50 ml/min) disease * Cannot receive furosemide, allergy to sulfa or sulfa-containing medications * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements