Lamivudine and Plasma Markers of Inflammation in Retinal Detachment

Inclusion Criteria: * Age ≥ 18 or ≤ 75 years * Patients with rhegmatogenous retinal detachment that require vitrectomy surgery Exclusion Criteria: * Previous pars plana vitrectomy in the affected eye * Positive for Hepatitis B surface antigen or HIV antibodies, or history of Hepatitis B/HIV * Pregnant or breast-feeding * Liver disease or abnormal AST/ALT * Renal impairment (Creatinine clearance \< 50) * Diabetes with current use of insulin * Anemia (Hemoglobin \<13.2 g/dL (male) or \< 11.6 g/dL (female)) * Unwilling to hold concurrent use of sorbitol or sorbitol-containing medications or products while taking study medication(including, but not limited to: blackberries, raspberries, strawberries, stone fruits, apples, avocados, sugar-free items such as chewing gum, hard candies, snack bars, frozen desserts, and chocolates, liquid and capsule/caplet analgesics, cough/cold/flu syrup, liquid and capsule/caplet pseudoephedrine, chewable antacid tablets, liquid and capsule allergy medications, motion sickness and nausea medications) * Current use of trimethoprim-sulfamethoxazole * Pancreatitis or history of pancreatitis * Uncontrolled blood pressure (\> 160 mm Hg systolic or \>100 mm Hg diastolic) within the last 3 months, or current use of more than one anti-hypertensive medication * History of stroke, myocardial infarction, or congestive heart failure * Current vitreous hemorrhage that obscures view of retinal details * Patients with a shallow anterior chamber or in whom anterior chamber paracentesis is considered unsafe