This study aims to compare the penile skin graft and buccal mucosal graft for substitution of long anterior urethral strictures using one-sided dorsal perineal approach.
Since previous studies were: * Retrospective and very few were prospective randomized studies * Some studies were done on lichen sclerosis cases that have an adverse effect on the PSG outcome. * The follow-up duration was longer for PSG patients. * Stricture length was usually longer for PSG cases. This study aims to compare the PSG and BMG for substitution of long anterior urethral strictures using one-sided dorsal perineal approach. The investigators hypothesize that: ❶ Conducting a well-designed prospective, randomized study can help identify which technique is better than the other. ❷ Using the one-side dorsal approach can improve the outcomes of both techniques and identify their advantages and disadvantages.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
substitution of long anterior urethral strictures using one-sided dorsal perineal approach
substitution of long anterior urethral strictures using one-sided dorsal perineal approach
Al-Azhar urology department, Al-Azhar university hospitals
Cairo, Egypt
RECRUITINGThe degree of urethral lumen patency.
Patent urethra as evidenced by uroflowmetry and retrograde urethrography +/- urethroscopy
Time frame: through study completion, an average of 1 year.
Lower urinary tract symptoms improvement
lower urinary tract symptoms as assessed by the international prostate symptom score, ranging from 0 to 35, where scores from 0-7 are mild, from 8-19 are moderate, from 20-35 are severe symptoms.
Time frame: 6 months
Erectile function assessment
sexual function as assessed by the international index of erectile function-5 questionnaire, ranging from 5-25, where 22-25 is normal, 17-21 is mild ED, 12-16 is mild to moderate ED, 8-11 is moderate ED, and 5-7 is severe ED.
Time frame: 6 months
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