Obesity is closely related to many chronic diseases such as hypertension, coronary heart disease, hyperlipidemia, type 2 diabetes, fatty liver, certain types of tumors, etc, which are associated with adverse health outcomes. Limiting energy intake is one of the most important treatment measures for weight loss. The fruits of Aronia melanocarpa (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human health, including antidiabetic, anti-infective, antineoplastic, antiobesity, antioxidant and gut microbiota-regulating activities. Thus, it is worth investigating whether consumption of aronia melanocarpa extract have additional benefits in improving anthropometric indicators, glucose and lipid metabolism, inflammatory status, adipocyte cytokines, and intestinal microbiota in obese individuals on the basis of an energy-restricted diet. Obese individuals will be divided into intervention group and control group in this 8-week trial. Both groups will be given an energy-restricted diet, with an additional dose of aronia melanocarpa extract in capsules in intervention group and an additional dose of maltodextrin in capsules in control group. Fecal and blood samples from participants before and after the intervention will be collected for the analysis of gut microbiota, glucose and lipid metabolism, inflammatory status, and adipocyte cytokines
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
72
aronia melanocarpa extract (each capsule contains 150 mg of anthocyanins and 30 mg of flavonoidst;twice a day,one at a time) combined with an energy-restricted diet
gut microbiota
High flux sequencing of fecal specimens
Time frame: 8 weeks
glucose metabolism
Fasting blood glucose (in mmol/L)
Time frame: 8 weeks
glucose metabolism
fasting insulin (in μIU/L)
Time frame: 8 weeks
glucose metabolism
glycosylated hemoglobin (in %)
Time frame: 8 weeks
lipid metabolism
total cholesterol (in mmol/L)
Time frame: 8 weeks
lipid metabolism
triglycerides (in mmol/L)
Time frame: 8 weeks
lipid metabolism
high-density lipoprotein cholesterol (in mmol/L)
Time frame: 8 weeks
lipid metabolism
low-density lipoprotein cholesterol (in mmol/L)
Time frame: 8 weeks
leptin
serum leptin (in ng/ml)
Time frame: 8 weeks
adiponectin
serum adiponectin (in μg/ml)
Time frame: 8 weeks
Inflammatory cytokine
serum interleukin-1 (in pg/mL)
Time frame: 8 weeks
Inflammatory cytokine
serum interleukin-6 (in ng/L)
Time frame: 8 weeks
Inflammatory cytokine
tumor necrosis factor-α (in pg/ml)
Time frame: 8 weeks
Inflammatory cytokine
hypersensitive C-reactive protein (in mg/L)
Time frame: 8 weeks
Anthropometrics
Body weight (in kg)
Time frame: 8 weeks
Anthropometrics
waist circumference (in cm)
Time frame: 8 weeks
Anthropometrics
BMI in kg/m\^2
Time frame: 8 weeks
body composition
including body fat (in %), fat-free mass (in kg)
Time frame: 8 weeks
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