This is a descriptive, prospective, single centre study. This study will assess PSMA expression via the uptake of radiolabelled PSMA-ligand using PET/CT imaging in mTNBC lesions pre-identified on 18F-FDG PET/CT in order to evaluate the feasibility of molecular radionuclide therapy in refractory mTNBC using the Lutetium-177 radiolabelled PSMA.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
20
Patient undergo Ga-PSMA PET/CT prior to the start of the new drug treatment
Institut Jules Bordet
Brussels, Belgium
RECRUITINGAssess PSMA expression in progressive metastatic TNBC patients
uptake of radiolabelled PSMA-ligand in patients with mTNBC on PET/CT images.
Time frame: once at baseline prior to the start of the new anti cancer treatment
Assess the concordance between lesions visualized on PSMA PET/CT and 18F-FDG PET/CT images (or brain MRI in case of brain metastases).
Matching between FDG and PSMA-labelled radiotracers uptake: on PSMA PET/CT and 18F-FDG PET/CT images, each lesion will be identified and faced with the other images. Each imaging pair will be classified as complete match, partial match or no match between the different types of imaging
Time frame: once at baseline prior to the start of the new anti cancer treatment
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