Effect of Collagen Peptides, in Combination With Resistance Training, on Body Composition and Muscle Strength in Untrained Men

University of Southern Denmark80 enrolled

Overview

The effect of resistance training with post-exercise Collagen peptides (CP) supplementation on lean body mass, maximal and explosive, isometric muscle strength as well as fat mass, resting metabolism, health parameters and compared to resistance training alone will be evaluated in a group of untrained overweight male (30-60 yrs) population in a randomized controlled trial (RCT).

Participants will perform supervised resistance training involving (Leg press, pull down, chest press, back extension and abdominal crunches) 3 times a week for 12 weeks. Participants will consume either placebo or collagen peptides (in a double blinded study design) just following resistance training on training days (And approximately the same time of day on non-training days). Prior to, and following 12 weeks of exercise, participants will be tested in body composition, maximal and explosive, isometric muscle strength, resting metabolism, health parameters. Additionally, blood samples will be taken to ensure health and training eligibility and safety. Participants are healthy untrained overweight males (30-60 yrs)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Body Composition Lean Body Mass

Eligibility

Sex: MALEMin age: 30 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male, between 30 and 60 years of age * Fat mass \>25 % as measured by bioelectrical impedance analysis * Stable weight (±5 %) and eating behaviour within the last 3 months. * Signed informed consent Exclusion Criteria: * Regular physical activity \>60 min / week * Stabile or progressive diseases/conditions (including medication) contraindicating or disabling participation in intensive exercise training and/or with potential to affect training adaptation beyond normal variation. For example: * Contraindications against physical stress corresponding guidelines of American College of Sports Medicine (ACSM) * Subjective symptoms during exercise (e.g., unusual physical exhaustion, dyspnoea, nausea) * Moderate to severe mobility limitation (i.e., due to rheumatic disease) * Diagnosis of cancer within the last 5 years * Diabetes mellitus I and II uncontrolled arterial hypertension (systolic blood pressure \>155 for mmHg and/or diastolic blood pressure \>94 mm Hg; mild hypertension under resting condition will be allowed but such participants will be recommended to consult their general practitioner). * Conditions contraindicating the supplementation protocol. * Contraindications against nutritional or ergogenic supplements * Allergy/aversion against animal protein * Liver or kidney diseases with a non-permission to ingest certain concentrations of protein.

Outcomes

Primary Outcomes

Lean body mass (kg)

Lean body mass measured by dual-energy X-ray absorptiometry (DXA)

Time frame: Pre (1week prior to intervention) and post (1 week following intervention. i.e 14weeks after inclusion) intervention - about 20 minutes for all dxa-measurements

Secondary Outcomes

Fat mass (kg)

Fat mass measured by dual-energy X-ray absorptiometry (DXA)

Time frame: Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 20 minutes for all dxa-measurements

Resting energy expenditure (kcal pr. day)

Resting energy expenditure measured with the ventilated hood and indirect calorimetry

Time frame: Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - 15-25 minutes in total

1 Repetition maximum strength (kg)

1 repetition maximum strength in leg press, pull down and chest press

Time frame: Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all 1RM measurements

Maximal isometric knee extensor force (Nm)

Maximal isometric knee extensor force

Time frame: Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all isokinetic dynamometer measurements

Rate of force development (Nm/sec)

Unilateral rate of force development from onset of force until 0-30, 0-50, 0-100, 0-200ms of the knee extensor

Time frame: Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all isokinetic dynamometer measurements

Knee extensor power (W)

Unilateral knee extensor power (W)

Time frame: Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 15 minutes

Sit to stand

30 second sit to stand test

Time frame: Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 3 minutes

Full body bone mineral density (g/cm^2)

Full body bone mineral density (BMD) (obtained by DEXA)

Time frame: Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 20 minutes for all dxa-measurements

Blood sampling

Blood samples collected from the antecubital vein in a fasted state. Measurements of Hb1Ac, insulin, glucose, total cholesterol, high density lipoprotein, low density lipoprotein, triglycerides, HOMA-IR, Non-HDL cholesterol (Total - HDL), Total cholesterol / HDL ratio

Time frame: Pre (1week prior to intervention) and post (1 week following intervention. i.e 14weeks after inclusion) intervention - about 3 minutes