Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. The most classic pathway to trigger allergy is type I allergy mediated by immunoglobulin E(IgE), but the role of immunoglobulin G4(IgG4) in allergic diseases is still worth exploring.we have collected the data of allergic patients aged 0-14 years for retrospective cross-sectional analysis to evaluate the positive rates of total IgE, HDM IgE, FS-IgE and FS-IgG4. Meanwhile, investigators screened out patients who were treated with FS-IgG4-guided elimination diets with/without probiotics for more than 3 months to clarify the role of FS-IgG4 in childhood allergic diseases by assessing the improvement of clinical symptoms before and after treatment.
Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. And management of allergic diseases beyond medication, such as food management is also very important. The most classic pathway to trigger allergy is type I allergy mediated by immunoglobulin E(IgE), but the role of immunoglobulin G4(IgG4) in allergic diseases is still worth exploring.In present study, investigators have collected the data of allergic patients aged 0-14 years for retrospective cross-sectional analysis to evaluate the positive rates of total IgE, house dust mite (HDM) IgE, FS-IgE and FS-IgG4. Meanwhile, investigators screened out patients who were treated with FS-IgG4-guided diet elimination with/without probiotics for more than 3 months to clarify the role of FS-IgG4 in childhood allergic diseases by assessing the improvement of clinical symptoms before and after treatment. This retrospective study was conducted to clarify the clinical relevance of food-specific IgG4 in allergic diseases and the effect of dietary avoidance on clinical symptoms, thus making a breakthrough in the diagnosis and treatment of childhood allergies.
Study Type
OBSERVATIONAL
Enrollment
407
Second Affiliated Hospital，School of Medicine，Zhejiang University
Hangzhou, Zhejiang, China
Age of participants
Age of participants were evaluated in the respiratory, dermatological and multisystemic groups.
Time frame: 2018.1-2020.12
Gender ratio of participants
Gender ratio of participants were evaluated in the respiratory, dermatological and multisystemic groups.
Time frame: 2018.1-2020.12
birth mode of participants
Birth mode of participants were evaluated in the respiratory, dermatological and multisystemic groups.
Time frame: 2018.1-2020.12
Family history of allergies of the participants
Family history of allergies of the participants were evaluated in the respiratory, dermatological and multisystemic groups.
Time frame: 2018.1-2020.12
total IgE
The average level of total IgE in the respiratory, cutaneous, and multi-system groups was assessed.
Time frame: 2018.1-2020.12
FS-IgE
The positive rates of FS-IgE in respiratory, cutaneous and multi-system groups were evaluated.
Time frame: 2018.1-2020.12
HDM-IgE
The average level of HDM-IgE in the respiratory, cutaneous, and multi-system groups was assessed.
Time frame: 2018.1-2020.12
FS-IgG4
The positive rates of FS-IgG4 in respiratory, cutaneous and multi-system groups were evaluated.
Time frame: 2018.1-2020.12
The difference of total-IgE and FS-IgG4 positive rates among the three groups
Chi-square test was used to compare total-IgE (+) FS-IgG4 (+), total-IgE (+) FS-IgG4 (-), total-IgE (-) FS-IgG4 (+) and total-IgE (-) FS-IgG4 (-) among the three groups.
Time frame: 2018.1-2020.12
The difference of FS-IgE and FS-IgG4 positive rates among the three groups
Chi-square test was used to compare FS-IgE (+) FS-IgG4 (+), FS-IgE (+) FS-IgG4 (-), FS-IgE (-) FS-IgG4 (+) and FS-IgE (-) FS-IgG4 (-) among the three groups.
Time frame: 2018.1-2020.12
Comparison of FS-IgG4 positive rates among the three groups
The differences of 10 food-specific IgG4 antibodies (including eggs, milk, cod, beef, chicken, wheat, prawns, crab, mushrooms) in respiratory, skin and multi-system groups were evaluated.
Time frame: 2018.1-2020.12
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