On the basis of previous research, this subject intends to evaluate the liver improvement of patients with liver disease after weight loss by MRI, and quantify it by extracting features, so as to provide a new method to judge the liver status of patients with liver disease, and to evaluate the correlation between the inflammatory status of patients and the quantitative features of MRI, and try to explain the reasons for the improvement of fatty liver status of patients with liver disease after weight loss. To provide a new theoretical basis for fatty liver and systemic inflammatory liver damage in patients with liver disease after weight loss surgery, and to link them, and try to explain the improvement of fatty liver in patients with liver disease through the reduction of systemic inflammatory level.
This study is a prospective study to explore the improvement of fatty liver and severe state of the whole body in patients with liver disease undergoing weight-loss surgery. The research object is obese patients who underwent laparoscopic sleeve gastrectomy in our hospital. According to the standard of accepting the discharge, about 50 patients were selected and divided into groups according to preoperative, postoperative one month, postoperative three months and postoperative six months.All patients underwent routine sequence examinations using a Siemens 3.0T MRI scanner (MAGNETOM Prisma, Siemens Healthcare, Munich, Germany).This study investigates alterations in NAFLD among patients with obesity who underwent bariatric surgery using MRI-PDFF and MRS techniques. Additionally, we evaluated the factors that may influence these changes in patients after the surgical procedure.
Study Type
OBSERVATIONAL
Enrollment
50
We do not have any intervention type
Qingdao University Affiliated Hospital
Qingdao, Shandong, China
RECRUITINGLiver fat fraction
The primary outcome was a indicator for evaluating liver fat content.
Time frame: before surgery、one 、three、six month after surgery
white blood cell
The primary outcome was a indicator for evaluating inflammation.
Time frame: before surgery、one 、three、six month after surgery
aspartate aminotransferase
The primary outcome was a indicator for evaluating liver function.
Time frame: before surgery、one 、three、six month after surgery
alanine aminotransferase
The primary outcome was a indicator for evaluating liver function.
Time frame: before surgery、one 、three、six month after surgery
C-reactive protein
The primary outcome was a indicators for evaluating inflammation.
Time frame: before surgery、one 、three、six month after surgery
neutrophile granulocyte
The primary outcome was a indicator for evaluating inflammation.
Time frame: before surgery、one 、three、six month after surgery
low-density lipoprotein
The secondary outcome was a indicator for evaluating blood fat.
Time frame: before surgery、one 、three、six month after surgery
high-density lipoprotein
The secondary outcome was a indicator for evaluating blood lipid.
Time frame: before surgery、one 、three、six month after surgery
glucose
The secondary outcome was a indicator for evaluating blood glucose.
Time frame: before surgery、one 、three、six month after surgery
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