Low-Frequency REpetitive TRanscranial Magnetic Stimulation in ACute Ischemic StrokE Within 48 Hours

Inclusion Criteria: 1. Age 18-80 years, gender is not limited; 2. Acute ischemic stroke of anterior circulation was diagnosed clinically 3. mRS 0-1 score before onset; 4. 6 ≤ NIHSS ≤25 at randomization; 5. Within 48 hours of stroke onset; 6. No thrombolysis therapy or thrombectomy is planned; 7. Obtain informed consent signed by the patient himself or by his legal authorized representative. Exclusion Criteria: 1. TMS contraindications include metallic foreign bodies in the head, pacemaker, implantable drug pumps, cochlear implants, etc. 2. Epilepsy or history of epilepsy, intracranial hypertension, tumor and other serious neurological disorders; 3. Midline displacement and brain parenchymal mass effect seen in head CT and other images; 4. Head CT or MRI showed bilateral acute cerebral infarction, brainstem infarction, or insular infarction; 5. Evidence of acute intracranial hemorrhage; 6. A history of congenital or acquired hemorrhagic disease, coagulation factor deficiency, or thrombocytopenia disease; 7. After blood pressure control, the systolic blood pressure was still ≥180 mmHg or the diastolic blood pressure was ≥110 mmHg; 8. Known recent or current serum creatinine exceeding 1.5 times the upper limit of normal or estimated glomerular filtration rate (EGFR) \< 60 mL/min; 9. Patients during pregnancy or lactation and within 90 days of planned pregnancy; 10. Patients with severe mental disorders or dementia who can not cooperate with informed consent and follow-up; 11. Patients with malignancy or severe systemic disease and expected survival of less than 90 days; 12. Participants in other clinical intervention studies within 30 days before randomization or who were participating in other clinical intervention studies.