The COVID-19 pandemic severely impacted the medical system both directly but also through incomplete recovery from the virus in the form of post-acute sequelae of COVID-19 (PASC). PASC affects at least 9.6 million individuals as of May 2022 and continues to affect many more. PASC is a multisystem disorder often presenting with mental fog, dyspnea on exertion, and fatigue among other symptoms. The etiology of PASC is uncertain but theories include direct cytotoxicity, dysregulated immune responses, endotheliitis associated with microthrombi, eNOS uncoupling, and myocardial fibrosis with impaired ventricular compliance. To date, there are no established treatments. Exercise has the potential as a therapeutic option to improve VO2peak and improve each of the aforementioned underlying etiologies. The investigators plan to examine the effect of High-Intensity Interval Training (HIIT) and Moderate intensity exercise training (MOD) on the symptoms and exercise tolerance of patients with PASC. The investigators approach will consist of a randomized, blinded, 2-arm, parallel-group design. Enrolled subjects will be randomly assigned to one of two groups in a 1:1 allocation ratio. All groups will undergo a 4-week intervention of 3 days of HIIT per week and 2 days of MOD per week or control of light stretching and controlled breathing. Subjects will be assessed before and after the 4-week intervention to examine the extent to which 4 weeks of the HIIT and MOD combination improves VO2peak and left ventricular diastolic function, global longitudinal strain (GLS), and global circumferential strain (GCS). Further, the investigators will explore changes in markers such as heart rate, heart rhythm, blood pressure, quality of life, exercise tolerance, and PASC symptoms as well as blood/serum markers.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Patients will perform 5 days of supervised stationary cycling exercise (with EKG telemetry) per week over a period of 4 weeks. Training heart rates will be determined based on the pre-testing VO2peak and peak heart rate (PHR). * Of the 5 sessions, 3 will be HIIT sessions and 2 will be MOD sessions. * Subjects exercising on the HIIT day will start with eight intervals of 2-min duration at 80-85% of PHR, separated by 2 min of recovery at 50% of PHR, progressing to four, 4-min intervals at 90-95% PHR, separated by 3 min at 50% PHR by the end of week 2. * Subjects exercising on the MOD days will perform uninterrupted for 40 minutes duration at 60-65% of PHR progressing to 40 minutes duration at 70-75% of PHR by the end of week 2. * Each training session will begin with a 10-min warm-up at 50% PHR and end with a 5-min cool down at 50% PHR. Exercise progression may have to be modified according to individual subject exercise tolerance.
University of Virginia University Hospital
Charlottesville, Virginia, United States
VO2peak
Change in VO2peak (L/min) measured pre- and post-intervention
Time frame: 4 weeks
Left ventricular strain
Global longitudinal strain and global circumferential strain measured pre- and post-intervention
Time frame: 4 weeks
Left ventricular diastolic function
Diastolic dysfunction grade measured pre- and post-intervention
Time frame: 4 weeks
Forced expiratory volume in one second (FEV1)
FEV1 measured via spirometry pre- and post-intervention
Time frame: 4 weeks
Forced vital capacity (FVC)
FVC measured via spirometry pre- and post-intervention
Time frame: 4 weeks
Post COVID-19 Functional Status scale
Measures subjects functional limitations due to COVID-19 and will be measured via pre- and post-intervention
Time frame: 4 weeks
Symptom Burden Questionnaire for Long Covid (SBQ-LC)
Burden of symptoms will be via the SBQ-LC measured pre- and post-intervention
Time frame: 4 weeks
International Physical Activity Questionnaire (IPAQ)
Physical activity levels will be assessed via IPAQ measured pre- and post-intervention
Time frame: 4 weeks
NTproBNP
Assess changes in NTproBNP (pg/ml) as a biomarker of myocardial strain at pre- and post-intervention
Time frame: 4 weeks
C-reactive protein (CRP)
C-reactive protein (mg/dl) will be used as a biomarker for inflammation to be measured pre- and post-intervention
Time frame: 4 weeks
Lipids
A lipid panel will be performed to measure total cholesterol, triglycerides, high-density lipoproteins, and low-density lipoprotein (mg/dl) to assess changes in cardiometabolic health pre- and post-intervention
Time frame: 4 weeks
Fasting glucose
Fasting blood glucose levels (mg/dl) will be tested to assess changes in cardiometabolic health pre- and post-intervention
Time frame: 4 weeks
Insulin
Fasting insulin levels (U/ml) will be tested to assess changes in cardiometabolic health pre- and post-intervention
Time frame: 4 weeks
Erythrocyte sedimentation rate (ESR)
ESR will be measured to assess inflammation pre- and post-intervention
Time frame: 4 weeks
IL-1
Inflammation will be measured via IL-1 pre- and post-intervention
Time frame: 4 weeks
IL-6
Inflammation will be measured via IL-6 pre- and post-intervention
Time frame: 4 weeks
TNF-a
Inflammation will be measured via TNF-a pre- and post-intervention
Time frame: 4 weeks
Fibrinogen
Fibrinogen will be measured pre- and post-intervention to measure clotting
Time frame: 4 weeks
D-dimer
D-dimer will be measured pre- and post-intervention to measure clotting
Time frame: 4 weeks
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