Prophylactic Pregabalin Treatment Following Spinal Cord Injury

Loewenstein Hospital50 enrolled

Overview

Patients arriving to rehabilitation up to 3 months following SCI will be given (study group) or not (control group) Lyrica (75X2). They will be followed for central pain development.

Patients arriving to rehabilitation up to 3 months following SCI will be recruited, if they have not yet developed central pain. Two thirds (the study group) will be treated with Lyrica (Pregabalin75X2) for 3 months. One third (the control group) will not receive preventative treatment. Participants will be followed for central pain development.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Spinal Cord Injuries Spinal Cord Diseases

Interventions

Pregabalin 75mgDRUG

Pregabalin 75 mg twice a day

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Up to 3 months following traumatic or non-traumatic SCL * Ability to give informed consent and cooperate Exclusion Criteria: * Pregnancy * Neurological or other medical conditions that may interfere with sensation * Neuropathic-like pain before recruitment (described as painful sensation of electric current, burning, numbness, tingling, pricking, or squeezing) * Being treated with Pregabalin * Blood creatinine levels \>1.2 or creatinine clearance \<60 * Sensitivity to lactose

Locations (1)

Loewenstein Rehabilitation Hospital

Raanana, Israel

RECRUITING

Outcomes

Primary Outcomes

Central pain

development of central pain by interview (yes /no )

Time frame: 1 year

McGill Pain Questionnaire

Range 0 -78. higher scores mean worse outcome.

Time frame: 3 months

Central Contacts

Amiram Catz, Prof.

CONTACT

972-9-770-9934 amiramc@clalit.org.il

Data from ClinicalTrials.gov

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