Perioperative Analgesia in Neonates Who Underwent Primary Cleft Lip Repair Surgery

Brno University Hospital111 enrolled

Overview

In retrospective data search the investigators will identified the cumulative consumption of opioid analgesics during surgery and 24 hours after surgery in neonate with cleft lips who underwent primary cleft lip repair surgery.

The cumulative consumption of opioids during surgery and 24 hours after surgery in neonates with cleft lips who underwent primary cleft lip repair surgery is not known. Patients were divided into two groups according to the time period when they underwent surgery. Group 1 were neonates who underwent primary cleft lip repair surgery under general anaesthesia without regional anaesthesia - the time period before regional anesthesia is introduced into the standard procedure. Group 2 are newborns who underwent primary cleft lip repair surgery under general anaesthesia with regional anaesthesia. Group 1 underwent surgery in time period before regional anesthesia was introduced into the standard procedure. In this retrospective study, the anesthesiology perioperative data from January 2018 till December 2021 in the tertiary center of Pediatric anaesthesia will be evaluated.

Study Type

OBSERVATIONAL

Enrollment

111

Conditions

Perioperative Analgesia in Neonates

Interventions

the standard procedure - without regional anaesthesiaPROCEDURE

the standard procedure - without regional anaesthesia

infraorbital peripheral blockade with or without nasal peripheral blockade according to the preference of the anesthesiologist and surgeonPROCEDURE

infraorbital peripheral blockade with or without nasal peripheral blockade according to the preference of the anesthesiologist and surgeon

Eligibility

Sex: ALLMin age: 0 DaysMax age: 28 Days

Medical Language ↔ Plain English

Inclusion Criteria: * neonates with unilateral or bilateral cleft lip (U/BCL), all neonates with unilateral or bilateral cleft lip and alveolus (U/BCLA) or with unilateral or bilateral cleft lip, alveolus and palate (total cleft; U/BCLAP) who underwent cleft lip repair surgery in the neonatal period * the study period (1/2018-12/2021) Exclusion Criteria: * ● presence of coagulopathy * thrombocytopenia or thrombopathy * patients at risk of malignant hyperthermia * patients who were not neonates (older than 28 days) * patients who required postoperative mechanical ventilation

Locations (1)

Brno University Hospital

Brno, South Moravian, Czechia

Outcomes

Primary Outcomes

The cumulative consumption of opioids during surgery and 24 hours after surgery

The cumulative consumption of opioid analgesics during surgery and 24 hours after surgery in neonates with regional block compared to neonates without regional anesthesia

Time frame: 24 hours after surgery

Secondary Outcomes

Oral intake

Difference in time of first oral intake after surgery in the group with regional anesthesia compared to with the group without regional anaesthesia

Time frame: 24 hours after surgery

Complications

Complications of regional anesthesia including suction disorders in the group with regional anaesthesia

Time frame: 24 hours after surgery

Data from ClinicalTrials.gov

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