Shear Stress in the Arteries of the Lower Limbs During Exercise in Patients With Peripheral Arterial Disease

University of Nove de Julho15 enrolled

Overview

The aim of the study will be to evaluate shear stress and blood flow parameters in lower limb arteries during arm cycle ergometer exercise in participants with peripheral artery disease. Twenty patients participants with peripheral artery disease and claudication symptoms will be recruited. Participants will perform 3 experimental sessions in random order. Iarm-cranking (15 sets of two minutes exercise), warm water foot immersion, and control. During the interventions, blood pressure and heart rate will be assessed every 6 minutes. Measurements of arterial diameter, blood flow, anterograde and retrograde shear stress of the femoral artery will be evaluated using a two-dimensional ultrasound device with spectral Doppler.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Peripheral Arterial Disease

Interventions

Eligibility

Sex: ALLMin age: 50 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * clinical diagnosis of peripheral artery disease or ankle-brachial index less than 0.90 in one or both limbs * do not present peripheral neuropathy; * be able to exercise after medical approval * aged 50 or over. Exclusion Criteria: * Medication change during the study * Health problems that contraindicates the practice of physical exercise.

Outcomes

Primary Outcomes

Femoral artery diameter [mm]

Measurements will be obtained through duplex ultrasound in accordance with global recommendations.

Time frame: Before the intervention and at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 minutes into the intervention

Femoral artery shear rate [sec.-1]

Measurements will be obtained through duplex ultrasound in accordance with global recommendations.

Time frame: Before the intervention and at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 minutes into the intervention

Femoral artery Blood flow [mL/min]

Measurements will be obtained through duplex ultrasound in accordance with global recommendations.

Time frame: Before the intervention and at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 minutes into the intervention

Secondary Outcomes

Brachial systolic and diastolic blood pressure [mmHg]

Systolic and diastolic blood pressures will be assessment in the arms with an automatic blood pressure monitor (HEM-742, Omron Healthcare, Japan)

Time frame: Before the intervention and at 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, and 29 minutes into the intervention

Heart rate [bpm]

Heart rate assessment with a heart rate monitor (Polar H10, Polar®, Finland)

Time frame: Before and up to 30 minutes into the intervention

Shear Stress in the Arteries of the Lower Limbs During Exercise in Patients With Peripheral Arterial Disease

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes