Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune. The most common causes of pediatric uveitis are idiopathic and juvenile idiopathic arthritis-associated uveitis. Uveitis morbidities in pediatric patients include cataract, glaucoma, and amblyopia. Pediatric uveitis may be accopanied by involvement of the ocular vasculature, such as retinal vasculitis. We hypothesize that there are differences in systemic microcirculation between pediatric uveitis patients and healthy pediatric controls.
The systemic microcirculation will be investigated through nailfold capillaroscopic (NFC) assessment with noninfectious uveitis and healthy pediatric controls. The NFC parameters are: capillary density (number of capillaries per mm), dilated capillaries (apex of \>20µm), avascular areas, the presence of microhemorrhages, and capillary morphology (normal, multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries).
Study Type
OBSERVATIONAL
Enrollment
46
Maha Abdelrahman
Asyut, Egypt
capillary density by nailfold capillaroscopy
(number of capillaries per mm)
Time frame: 6 months
detection of number of dilated capillaries by nailfold capillaroscopy
number of dilated capillaries (apex of \>20µm)
Time frame: 6 months
detection of other abnormalities as avascular areas, microhemorrhages, and abnormal capillary morphology
detection of multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries
Time frame: 6 months
correlation of nailfold findings with uveitis activity
correlation of capillary abnormalities detected with active uveitis.
Time frame: 6 months
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